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Designing metal–peptide models for protein structure and function

2001; Elsevier BV; Volume: 5; Issue: 2 Linguagem: Inglês

10.1016/s1367-5931(00)00190-3

1879-0402

Gang Xing, Victoria J. DeRose,

Electrochemical sensors and biosensors

Recent progress in the rational design of metal sites within peptide model systems shows increasing control in the placement of metals within helical bundles and inclusion of sophisticated elements such as second-sphere ligand interactions. A crystallographically characterized two-metal peptide model for diiron proteins represents a major achievement in de novo design methodologies. Increasingly complex and robust models for electron transfer through and between helices, and electrode-supported electron-transfer peptides, have been constructed. Design elements for peptide-supported ferredoxins and mononuclear Fe(II) and Zn(II) sites have been refined.