Portal de Periódicos da CAPES

ELEVATED BLADDER URINE CONCENTRATION OF TRANSFORMING GROWTH FACTOR-beta 1 CORRELATES WITH UPPER URINARY TRACT OBSTRUCTION IN CHILDREN

1999; Lippincott Williams & Wilkins; Volume: 162; Issue: 3 Part 2 Linguagem: Inglês

10.1016/s0022-5347(01)68056-x

1527-3792

PETER D. FURNESS, Max Maizels, Sang Won Han, Richard A. Cohn, Earl Y. Cheng,

Kidney Stones and Urolithiasis Treatments

No AccessJournal of UrologyPapers Presented at Annual Meeting of the Section on Urology, American Academy of Pediatrics; San Francisco, California; October 17-19, 1998: Ureteropelvic Junction Obstruction1 Sep 1999ELEVATED BLADDER URINE CONCENTRATION OF TRANSFORMING GROWTH FACTOR-beta 1 CORRELATES WITH UPPER URINARY TRACT OBSTRUCTION IN CHILDREN PETER D. FURNESS, MAX MAIZELS, SANG WON HAN, RICHARD A. COHN, and EARL Y. CHENG PETER D. FURNESSPETER D. FURNESS , MAX MAIZELSMAX MAIZELS , SANG WON HANSANG WON HAN , RICHARD A. COHNRICHARD A. COHN , and EARL Y. CHENGEARL Y. CHENG View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)68056-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated urinary transforming growth factor-beta 1 (TGF-beta 1) concentration in children with upper urinary tract obstruction as a potential tool for supporting the diagnosis of clinically significant obstruction. Materials and Methods: Renal pelvic and bladder urine samples were obtained for analysis from 30 patients a median of 5 months old who underwent surgery for obstruction at the ureteropelvic (29) and ureterovesical (1) junctions. Urinary TGF-beta 1 concentration was measured using a quantitative sandwich enzyme-linked immunoassay technique. Bladder urine TGF-beta 1 in patients with obstruction was compared with that in controls. In addition, we compared renal pelvic and bladder urine TGF-beta 1 in patients with obstruction. Results: Mean bladder urine TGF-beta 1 plus or minus standard error of mean was 4-fold higher in patients with upper tract obstruction than in controls (195 +/- 29 versus 47 +/- 7 pg./mg. creatinine, p <0.001). In the obstructed group mean TGF-beta 1 in the renal pelvic urine was 378 +/- 86 pg./mg. creatinine, or twice that of the bladder urine (p = 0.02). Conclusions: Bladder urine TGF-beta 1 in patients with upper urinary tract obstruction is significantly elevated compared with that in controls. To our knowledge our study is the first to identify a bladder urinary marker that correlates with upper urinary tract obstruction with greater than 90% sensitivity. Measuring TGF-beta 1 in a voided bladder urine sample may provide an objective and noninvasive test for assisting in the diagnosis of upper urinary tract obstruction. References 1 : Urinary levels of renal tubular enzyme N-acetyl-beta-D-glucosaminidase in unilateral obstructive uropathy. J. Urol.1994; 151: 442. Link, Google Scholar 2 Cain, M., Regan, T., Mordkin, R., Gibbons, M. D. and Mulroney, S.: Alteration in urinary insulin-like growth factor following ureteral obstruction: a potential tool for quantifying acute and chronic obstructive renal injury. Read at annual meeting of Section on Urology, American Academy of Pediatrics, abstract 47, Boston, Massachusetts, October 26-28, 1997. Google Scholar 3 : Growth factors and apoptosis in neonatal ureteral obstruction. J. Amer. Soc. Nephrol.1996; 7: 1098. Crossref, Medline, Google Scholar 4 : Delayed treatment with enalapril halts tubulointerstitial fibrosis in rats with obstructive nephropathy. Kidney Int.1996; 49: 1110. Crossref, Medline, Google Scholar 5 : Increased expression of decorin in experimental hydronephrosis. Kidney Int.1997; 51: 1133. Crossref, Medline, Google Scholar 6 : Chronic unilateral ureteral obstruction is associated with interstitial fibrosis and tubular expression of transforming growth factor-beta. Lab. Invest.1996; 74: 528. Medline, Google Scholar 7 : TGF-beta mRNA expression in the renal pelvis after experimental and clinical ureteropelvic junction obstruction. J. Urol.1996; 156: 261. Link, Google Scholar 8 : Arrested development of the neonatal kidney following chronic ureteral obstruction. J. Urol.1996; 155: 1139. Link, Google Scholar 9 : Increased expression of TGF-beta mRNA in the obstructed kidney of rats with unilateral ureteral ligation. Kidney Int.1993; 44: 313. Crossref, Medline, Google Scholar 10 : Urine levels of transforming growth factor-beta 1 in children with ureteropelvic junction obstruction. Urology1997; 50: 5. Crossref, Google Scholar 11 : Ultrasound grading of hydronephrosis: introduction of the system by the Society for Fetal Urology. Ped. Rad.1993; 23: 478. Crossref, Medline, Google Scholar 12 : A well tempered diuretic renography: its historical development, physiological and technical pitfalls, and standard technique protocol. Sem. Nucl. Med.1992; 22: 74. Crossref, Medline, Google Scholar 13 : Determination of serum of creatinine by direct colorimetric method. Clin. Chim. Acta.1973; 43: 305. Crossref, Medline, Google Scholar 14 : Renal growth factor expression during the early phase of experimental hydronephrosis. J. Urol.1992; 148: 510. Link, Google Scholar 15 : Characterization of extracellular matrix, transforming growth factor-beta and interstitial macrophages in acute and chronic ureteral obstruction. J. Urol.1995; 153: 412A. abstract 735. Google Scholar 16 : Microanatomy and morphometry of the hydronephrotic obstructed renal pelvis in asymptomatic infants. J. Urol.1992; 148: 519. Link, Google Scholar 17 Poppas, D. P., Pigato, J., Scheinfeld, A., Vaughan, E. D., Jr. and Felsen, D.: Monoclonal antibody to transforming growth factor B (TGF-B) ameliorates interstitial fibrosis in complete unilateral ureteral obstruction (UUO) in rats. Read at annual meeting of Section on Urology, American Academy of Pediatrics, abstract 48, Boston, Massachusetts, October 26-28, 1997. Google Scholar 18 : Urine transforming growth factor-beta activity is related to the degree of scarring in crescentic nephritis in the rabbit. Nephron1993; 63: 73. Crossref, Medline, Google Scholar 19 : High molecular weight transforming growth factor beta is excreted in the urine in active nodular sclerosing Hodgkin's disease. Cancer Res.1992; 52: 6768. Medline, Google Scholar 20 : Increased excretion of urinary transforming growth factor beta in patients with focal glomerular sclerosis. Nephron1994; 66: 391. Crossref, Medline, Google Scholar From the Divisions of Pediatric Urology and Nephrology, Children's Memorial Hospital, and Department of Urology and Pediatrics, Northwestern University Medical School, Chicago, Illinois© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited by Xiao M, Zheng L, Zhang X, Duan X, Hang T, Lu S, Liu S and Lin H (2021) Renal-on-Chip Microfluidic Platform with a Force-Sensitive Resistor (ROC-FS) for Molecular Pathogenesis Analysis of HydronephrosisAnalytical Chemistry, 10.1021/acs.analchem.1c03155, VOL. 94, NO. 2, (748-757), Online publication date: 18-Jan-2022. Keshri R, Govindarajan K, Rajappa M, Sambandan K, Naredi B and Jindal B (2021) Can urinary biomarkers be used in the outcome assessment of pyeloplasty in children?African Journal of Urology, 10.1186/s12301-021-00217-y, VOL. 27, NO. 1, Online publication date: 1-Dec-2021. Turczyn A, Pańczyk-Tomaszewska M, Krzemień G, Górska E and Demkow U (2021) The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive NephropathyJournal of Clinical Medicine, 10.3390/jcm10214899, VOL. 10, NO. 21, (4899) Yiğit D, Taşkınlar H and Avlan D (2021) Can serum Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule−1 help in decision making for surgery in antenatally dedected hydronephrosisJournal of Pediatric Urology, 10.1016/j.jpurol.2020.10.013, VOL. 17, NO. 1, (71.e1-71.e7), Online publication date: 1-Feb-2021. Özkuvancı Ü, Dönmez M, Ziylan O, Oktar T, Küçükgergin C, Çetin B, Erdem S and Seçkin Ş (2020) Can urinary biomarkers detect obstruction defined by renal functional loss in antenatal hydronephrosis?Journal of Pediatric Urology, 10.1016/j.jpurol.2020.09.005, VOL. 16, NO. 6, (844.e1-844.e7), Online publication date: 1-Dec-2020. Jain V, Kumar R, Arora S, Mani K, Agarwala S, Yadav D, Goel P and Dhua A (2020) Cortical transit time: understanding utility and pitfalls in children with pelviureteric junction obstructionJournal of Pediatric Urology, 10.1016/j.jpurol.2020.02.008, VOL. 16, NO. 3, (330.e1-330.e6), Online publication date: 1-Jun-2020. Fernandes-Rosa F (2019) Pseudohypoaldosteronism Type 1 Encyclopedia of Endocrine Diseases, 10.1016/B978-0-12-801238-3.65188-7, (696-702), . Alipour A, Mohammadjafari H, Rafiei A and Amjadi O (2016) The Role of Urinary Biomarker Levels in Assessing the Presence and Severity of Ureteropelvic Junction Obstruction in Children: A Systematic Review and Meta-AnalysisJournal of Pediatrics Review, 10.17795/jpr-7567, VOL. 4, NO. 2 Seven A, Savran B, Koçak E, Tok S, Yüksel K, Gözükara İ and Kabil Kucur S (2015) Is there a correlation between maternal serum TGF- β 1 levels and fetal hydronephrosis? The Journal of Maternal-Fetal & Neonatal Medicine, 10.3109/14767058.2015.1036022, VOL. 29, NO. 7, (1113-1116), Online publication date: 2-Apr-2016. Gerber C, Harel M, Lynch M, Herbst K, Ferrer F and Shapiro L (2016) Proximal tubule proteins are significantly elevated in bladder urine of patients with ureteropelvic junction obstruction and may represent novel biomarkers: A pilot studyJournal of Pediatric Urology, 10.1016/j.jpurol.2015.10.008, VOL. 12, NO. 2, (120.e1-120.e7), Online publication date: 1-Apr-2016. Atar A, Oktar T, Kucukgergin C, Kalelioglu I, Seckin S, Ander H, Ziylan O and Kadioglu T (2015) The roles of serum and urinary carbohydrate antigen 19-9 in the management of patients with antenatal hydronephrosisJournal of Pediatric Urology, 10.1016/j.jpurol.2014.12.012, VOL. 11, NO. 3, (133.e1-133.e5), Online publication date: 1-Jun-2015. Chen X, Zhu W, Al-Hayek S, Yan X, Jiang C, Zheng X and Guo H (2014) Urinary TGF-1 has a supplementary value in predicting renal function recovery post unilateral ureteral obstructionInternational Urology and Nephrology, 10.1007/s11255-014-0846-3, VOL. 47, NO. 1, (33-37), Online publication date: 1-Jan-2015. Papachristou F, Pavlaki A and Printza N (2014) Urinary and serum biomarkers in ureteropelvic junction obstruction: a systematic reviewBiomarkers, 10.3109/1354750X.2014.943292, VOL. 19, NO. 7, (531-540), Online publication date: 1-Nov-2014. Vemulakonda V, Yiee J and Wilcox D (2014) Prenatal Hydronephrosis: Postnatal Evaluation and ManagementCurrent Urology Reports, 10.1007/s11934-014-0430-5, VOL. 15, NO. 8, Online publication date: 1-Aug-2014. McHugh K (2013) Megabladder mouse model of congenital obstructive nephropathy: genetic etiology and renal adaptationPediatric Nephrology, 10.1007/s00467-013-2658-6, VOL. 29, NO. 4, (645-650), Online publication date: 1-Apr-2014. Mandelia A, Bajpai M, Agarwala S, Gupta A, Kumar R and Ali A (2013) The role of urinary TGF-β1, TNF-α, IL-6 and microalbuminuria for monitoring therapy in posterior urethral valvesPediatric Nephrology, 10.1007/s00467-013-2506-8, VOL. 28, NO. 10, (1991-2001), Online publication date: 1-Oct-2013. Becknell B, Carpenter A, Allen J, Wilhide M, Ingraham S, Hains D, McHugh K and Long D (2013) Molecular Basis of Renal Adaptation in a Murine Model of Congenital Obstructive NephropathyPLoS ONE, 10.1371/journal.pone.0072762, VOL. 8, NO. 9, (e72762) Simões e Silva A, Valério F, Vasconcelos M, Miranda D and Oliveira E (2013) Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney DiseaseClinical and Developmental Immunology, 10.1155/2013/597920, VOL. 2013, (1-14), . Trnka P, Hiatt M, Tarantal A and Matsell D (2012) Congenital urinary tract obstruction: defining markers of developmental kidney injuryPediatric Research, 10.1038/pr.2012.113, VOL. 72, NO. 5, (446-454), Online publication date: 1-Nov-2012. Madsen M, Nørregaard R, Stødkilde L, Christensen J, Jørgensen T and Frøkiær J (2011) Urine and kidney cytokine profiles in experimental unilateral acute and chronic hydronephrosisScandinavian Journal of Urology and Nephrology, 10.3109/00365599.2011.637958, VOL. 46, NO. 2, (91-96), Online publication date: 1-Apr-2012. Pai B, Shaw N and Högler W (2011) Salt-losing crisis in infants—not always of adrenal originEuropean Journal of Pediatrics, 10.1007/s00431-011-1541-3, VOL. 171, NO. 2, (317-321), Online publication date: 1-Feb-2012. Casella D, Tomaszewski J and Ost M (2012) Posterior Urethral Valves: Renal Failure and Prenatal TreatmentInternational Journal of Nephrology, 10.1155/2012/351067, VOL. 2012, (1-4), . Groth T and Mitchell M (2012) Ureteropelvic Junction Obstruction Pediatric Surgery, 10.1016/B978-0-323-07255-7.00113-6, (1411-1425), . ZIEG J, BLAHOVA K, SEEMAN T, BRONSKY J, DVORAKOVA H, PECHOVA M, JANDA J and MATOUSOVIC K (2011) Urinary transforming growth factor-β1 in children with obstructive uropathyNephrology, 10.1111/j.1440-1797.2011.01459.x, VOL. 16, NO. 6, (595-598), Online publication date: 1-Aug-2011. Klein J, Gonzalez J, Miravete M, Caubet C, Chaaya R, Decramer S, Bandin F, Bascands J, Buffin-Meyer B and Schanstra J (2010) Congenital ureteropelvic junction obstruction: human disease and animal modelsInternational Journal of Experimental Pathology, 10.1111/j.1365-2613.2010.00727.x, VOL. 92, NO. 3, (168-192), Online publication date: 1-Jun-2011. Vasconcelos M, Bouzada M, Silveira K, Moura L, Santos F, Oliveira J, Carvalho F, Teixeira M, e Silva A and Oliveira E (2011) Urinary levels of TGF β-1 and of cytokines in patients with prenatally detected nephrouropathiesPediatric Nephrology, 10.1007/s00467-011-1802-4, VOL. 26, NO. 5, (739-747), Online publication date: 1-May-2011. Cho S, Choi L, Yim H, Yoo K, Hong Y and Lee J (2011) Clinical Significance of Electrolyte Imbalance in Pediatric Urinary Tract InfectionChildhood Kidney Diseases, 10.3339/jkspn.2011.15.1.58, VOL. 15, NO. 1, (58-65) Madsen M, Nørregaard R, Frøkiær J and Jørgensen T (2011) Urinary biomarkers in prenatally diagnosed unilateral hydronephrosisJournal of Pediatric Urology, 10.1016/j.jpurol.2010.12.004, VOL. 7, NO. 2, (105-112), Online publication date: 1-Apr-2011. Stajic N, Putnik J, Paripovic A and Bogdanovic R (2011) Transient pseudohypoaldosteronismSrpski arhiv za celokupno lekarstvo, 10.2298/SARH1102037S, VOL. 139, NO. 1-2, (37-43), . Drube J, Zürbig P, Schiffer E, Lau E, Ure B, Glüer S, Kirschstein M, Pape L, Decramer S, Bascands J, Schanstra J, Mischak H and Ehrich J (2010) Urinary proteome analysis identifies infants but not older children requiring pyeloplastyPediatric Nephrology, 10.1007/s00467-010-1455-8, VOL. 25, NO. 9, (1673-1678), Online publication date: 1-Sep-2010. Kajbafzadeh A, Elmi A, Talab S, Emami H, Esfahani S and Saeedi P (2010) Urinary and Serum Carbohydrate Antigen 19-9 as a Biomarker in Ureteropelvic Junction Obstruction in ChildrenJournal of Urology, VOL. 183, NO. 6, (2353-2360), Online publication date: 1-Jun-2010. Chevalier R, Thornhill B, Forbes M and Kiley S (2009) Mechanisms of renal injury and progression of renal disease in congenital obstructive nephropathyPediatric Nephrology, 10.1007/s00467-009-1316-5, VOL. 25, NO. 4, (687-697), Online publication date: 1-Apr-2010. Peters C (2010) CONGENITAL URINE FLOW IMPAIRMENTS OF THE UPPER URINARY TRACT Pediatric Urology, 10.1016/B978-1-4160-3204-5.00019-0, (237-247), . Bogdanović R, Stajić N, Putnik J and Paripović A (2009) Transient type 1 pseudo-hypoaldosteronism: report on an eight-patient series and literature reviewPediatric Nephrology, 10.1007/s00467-009-1285-8, VOL. 24, NO. 11, (2167-2175), Online publication date: 1-Nov-2009. Lee R (2009) Biomarkers for pediatric urological diseaseCurrent Opinion in Urology, 10.1097/MOU.0b013e32832c90ec, VOL. 19, NO. 4, (397-401), Online publication date: 1-Jul-2009. Almodhen F, Loutochin O, Capolicchio J, Jednak R and El-Sherbiny M (2009) The Role of Bladder Urine Transforming Growth Factor-β1 Concentrations in Diagnosis and Management of Unilateral Prenatal HydronephrosisJournal of Urology, VOL. 182, NO. 1, (292-298), Online publication date: 1-Jul-2009. Sager C, Lopez J, Duran V, Burek C and Perazzo E (2009) Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-upInternational braz j urol, 10.1590/S1677-55382009000300008, VOL. 35, NO. 3, (315-325), Online publication date: 1-Jun-2009. Lee H and Han S (2009) Ureteropelvic Junction Obstruction: What We Know and What We Don't KnowKorean Journal of Urology, 10.4111/kju.2009.50.5.423, VOL. 50, NO. 5, (423), . Chevalier R and Peters C (2009) Obstructive Uropathy Pediatric Nephrology, 10.1007/978-3-540-76341-3_56, (1337-1377), . Mataija-Botelho D, Murphy P, Pinto D, MacLellan D, Langlois C and Doucette A (2008) A qualitative proteome investigation of the sediment portion of human urine: Implications in the biomarker discovery processPROTEOMICS - Clinical Applications, 10.1002/prca.200800019, VOL. 3, NO. 1, (95-105), Online publication date: 1-Jan-2009. Decramer S, Bascands J and Schanstra J (2007) Non-invasive markers of ureteropelvic junction obstructionWorld Journal of Urology, 10.1007/s00345-007-0201-8, VOL. 25, NO. 5, (457-465), Online publication date: 18-Sep-2007. Taha M, Shokeir A, Osman H, Abd El-Aziz A and Farahat S (2007) Obstructed Versus Dilated Nonobstructed Kidneys in Children With Congenital Ureteropelvic Junction Narrowing: Role of Urinary Tubular EnzymesJournal of Urology, VOL. 178, NO. 2, (640-646), Online publication date: 1-Aug-2007. Taha M, Shokeir A, Osman H, Abd El-Aziz A and Farahat S (2007) Pelvi-ureteric junction obstruction in children: the role of urinary transforming growth factor-? 1 and epidermal growth factor BJU International, 10.1111/j.1464-410X.2006.06641.x, VOL. 99, NO. 4, (899-903), Online publication date: 1-Apr-2007. Taha M, Shokeir A, Osman H, Abd El-Aziz A and Farahat S (2007) Diagnosis of Ureteropelvic Junction Obstruction in Children: Role of Endothelin-1 in Voided UrineUrology, 10.1016/j.urology.2006.09.070, VOL. 69, NO. 3, (560-564), Online publication date: 1-Mar-2007. Conrad S (2007) Prognostische Marker bei kongenitalen HarntransportstörungenPrognostic markers for congenital hydronephrosesDer Urologe, 10.1007/s00120-007-1293-x, VOL. 46, NO. 2, (124-131), Online publication date: 1-Feb-2007. Shirazi M, Noorafshan A, Kroup M and Tanideh N (2009) Comparison of the effects of captopril, tamoxifen and L-carnitine on renal structure and fibrosis after total unilateral ureteral obstruction in the ratScandinavian Journal of Urology and Nephrology, 10.1080/00365590600917974, VOL. 41, NO. 2, (91-97), Online publication date: 1-Jan-2007. Zderic S (2006) Posterior urethral values The Kelalis-King-Belman Textbook of Clinical Pediatric Urology, Fifth Edition, 10.1201/b13795-69, (1059-1079), Online publication date: 21-Dec-2006. Murer L, Benetti E, Centi S, Della Vella M, Artifoni L, Capizzi A, Zucchetta P, Del Prete D, Carasi C, Montini G, Rigamonti W and Zaccello G (2018) Clinical and Molecular Markers of Chronic Interstitial Nephropathy in Congenital Unilateral Ureteropelvic Junction ObstructionJournal of Urology, VOL. 176, NO. 6, (2668-2673), Online publication date: 1-Dec-2006. Chevalier R (2006) Obstructive nephropathy: towards biomarker discovery and gene therapyNature Clinical Practice Nephrology, 10.1038/ncpneph0098, VOL. 2, NO. 3, (157-168), Online publication date: 1-Mar-2006. Thornhill B, Burt L, Chen C, Forbes M and Chevalier R (2005) Variable chronic partial ureteral obstruction in the neonatal rat: A new model of ureteropelvic junction obstruction1Kidney International, 10.1111/j.1523-1755.2005.00052.x, VOL. 67, NO. 1, (42-52), Online publication date: 1-Jan-2005. STEHR M, ESTRADA C, KHOURY J, DANCIU T, SULLIVAN M, PETERS C, SOLOMON K, FREEMAN M and ADAM R (2018) CAVEOLAE ARE NEGATIVE REGULATORS OF TRANSFORMING GROWTH FACTOR-β1 SIGNALING IN URETERAL SMOOTH MUSCLE CELLSJournal of Urology, VOL. 172, NO. 6 Part 1, (2451-2455), Online publication date: 1-Dec-2004.CHEVALIER R (2018) BIOMARKERS OF CONGENITAL OBSTRUCTIVE NEPHROPATHY: PAST, PRESENT AND FUTUREJournal of Urology, VOL. 172, NO. 3, (852-857), Online publication date: 1-Sep-2004. Chevalier R (2004) Perinatal Obstructive NephropathySeminars in Perinatology, 10.1053/j.semperi.2003.11.009, VOL. 28, NO. 2, (124-131), Online publication date: 1-Apr-2004. Vallés P, Pascual L, Manucha W, Carrizo L and Rüttler M (2003) Role of endogenous nitric oxide in unilateral ureteropelvic junction obstruction in childrenKidney International, 10.1046/j.1523-1755.2003.00833.x, VOL. 63, NO. 3, (1104-1115), Online publication date: 1-Mar-2003. EL-SHERBINY M, MOUSA O, SHOKEIR A and GHONEIM M (2002) Role of Urinary Transforming Growth Factor-??1 Concentration in the Diagnosis of Upper Urinary Tract Obstruction in ChildrenThe Journal of Urology, 10.1097/00005392-200210020-00034, (1798-1800), Online publication date: 1-Oct-2002. El-Sherbiny M, Mousa O, Shokeir A and Ghoneim M (2018) Role of Urinary Transforming Growth Factor-β1 Concentration in the Diagnosis of Upper Urinary Tract Obstruction in ChildrenJournal of Urology, VOL. 168, NO. 4 Part 2, (1798-1800), Online publication date: 1-Oct-2002. Chevalier R, Thornhill B, Chang A, Cachat F and Lackey A (2002) Recovery from release of ureteral obstruction in the rat: Relationship to nephrogenesisKidney International, 10.1046/j.1523-1755.2002.00359.x, VOL. 61, NO. 6, (2033-2043), Online publication date: 1-Jun-2002. Josephson S (2009) Antenatally Detected, Unilateral Dilatation of the Renal Pelvis: A Critical Review. 2. Postnatal Non-operative Treatment--Long-term Hazards, Urgent ResearchScandinavian Journal of Urology and Nephrology, 10.1080/003655902320248209, VOL. 36, NO. 4, (251-259), Online publication date: 1-Jan-2002. Liao J and Churchill B (2001) PEDIATRIC URINE TESINGPediatric Clinics of North America, 10.1016/S0031-3955(05)70384-9, VOL. 48, NO. 6, (1425-1440), Online publication date: 1-Dec-2001. Peters C (2001) Animal models of fetal renal diseasePrenatal Diagnosis, 10.1002/pd.211, VOL. 21, NO. 11, (917-923), Online publication date: 1-Nov-2001. Liatsikos E, Dinlenc C, Bernardo N, Kapoor R, Jabbour M, Smith A and Kushner L (2001) Endopyelotomy Failure Is Associated with Reduced Urinary Transforming Growth Factor- β 1 Levels in Patients with Upper Urinary Tract Obstruction Journal of Endourology, 10.1089/089277901750426300, VOL. 15, NO. 6, (567-570), Online publication date: 1-Aug-2001. Chevalier R (2018) EDITORIAL: CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACTJournal of Urology, VOL. 165, NO. 1, (203-204), Online publication date: 1-Jan-2001. MacRae Dell K, Hoffman B, Leonard M, Ziyadeh F and Schulman S (2000) Increased urinary transforming growth factor- beta1 excretion in children with posterior urethral valvesUrology, 10.1016/S0090-4295(00)00591-4, VOL. 56, NO. 2, (311-314), Online publication date: 1-Aug-2000. Volume 162Issue 3 Part 2September 1999Page: 1033-1036 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.Metrics Author Information PETER D. FURNESS More articles by this author MAX MAIZELS More articles by this author SANG WON HAN More articles by this author RICHARD A. COHN More articles by this author EARL Y. CHENG More articles by this author Expand All Advertisement PDF downloadLoading ...