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Chemical and Apoptotic Properties of Hydroxy-Ceramides Containing Long-Chain Bases with Unusual Alkyl Chain Lengths

2008; Oxford University Press; Volume: 144; Issue: 1 Linguagem: Inglês

10.1093/jb/mvn050

1756-2651

Mamoru Kyogashima, Keiko Tadano‐Aritomi, Toshifumi Aoyama, Akiko Yusa, Yoshiko Goto, Keiko Tamiya‐Koizumi, Hiromi Ito, Takashi Murate, Reiji Kannagi, Atsushi Hara,

Axial and Atropisomeric Chirality Synthesis

Journal Article Chemical and Apoptotic Properties of Hydroxy-Ceramides Containing Long-Chain Bases with Unusual Alkyl Chain Lengths Get access Mamoru Kyogashima, Mamoru Kyogashima * 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan *To whom correspondence should be addressed. Tel: +81 52 762 6111, Fax: +81 52 763 5233, E-mail: mkyogashi@aichi-cc.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Keiko Tadano-Aritomi, Keiko Tadano-Aritomi 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Toshifumi Aoyama, Toshifumi Aoyama 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Akiko Yusa, Akiko Yusa 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshiko Goto, Yoshiko Goto 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Keiko Tamiya-Koizumi, Keiko Tamiya-Koizumi 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiromi Ito, Hiromi Ito 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Takashi Murate, Takashi Murate 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Reiji Kannagi, Reiji Kannagi 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Atsushi Hara Atsushi Hara 1Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681; 2Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603; 3Department of Biochemistry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605; 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621; and 5Department of Medical Technology, Nagoya University Graduate School of Health Sciences, 1-1-20, Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 144, Issue 1, July 2008, Pages 95–106, https://doi.org/10.1093/jb/mvn050 Published: 16 April 2008 Article history Received: 29 February 2008 Accepted: 20 March 2008 Published: 16 April 2008