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Asymmetric Dimethylarginine and Augmentation Index in Newly Diagnosed Patients With Hypertension

2013; SAGE Publishing; Volume: 66; Issue: 1 Linguagem: Inglês

10.1177/0003319713513145

1940-1574

Mustafa Çakar, Fatih Bulucu, Murat Karaman, Seyıt Ahmet Ay, Ömer Kurt, Şevket Balta, Saıt Demırkol, Hakan Şarlak, Muharrem Akhan, Battal Altun, Halıl Yaman, Erol Arslan, Şeref Demirbaş, Kenan Sağlam,

Hemodynamic Monitoring and Therapy

Pulse wave velocity (PWV), augmentation index (Aix), and central aortic pressure (CAP) are arterial stiffness markers of endothelial dysfunction (ED). We investigated the relationship between arterial stiffness parameters and asymmetric dimethylarginine (ADMA; a marker of ED), in newly diagnosed patients with hypertension (n = 101; 61 females). These patients were investigated in accordance with the recommendations of hypertension guidelines. Arterial stiffness was measured, and serum ADMA and C-reactive protein (CRP; a marker of inflammation) levels were determined. In both women and men, there was no difference in terms of age, body mass index, systolic and diastolic blood pressures, PWV, CAP and the levels of ADMA, while Aix and CRP levels were significantly higher in women (P = .004, P = .046, respectively). In the whole group, ADMA levels correlated with Aix (Pearson r = .237, P = .024). Our findings provide further evidence of a link between arterial stiffness and ED in newly diagnosed patients with hypertension.