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General Multicomponent Strategy for the Synthesis of 2‐Amino‐1,4‐diazaheterocycles: Scope, Limitations, and Utility

2010; Wiley; Volume: 2010; Issue: 8 Linguagem: Inglês

10.1002/ejoc.200901360

1434-193X

Volodymyr Kysil, Alexander Khvat, Sergey Tsirulnikov, Sergey Tkachenko, Caroline Williams, M.V. Churakova, Alexandre V. Ivachtchenko,

Synthesis and biological activity

Abstract Multicomponent reactions of primary 1,2‐ and 1,3‐diamines with carbonyl compounds and isocyanides resulting in the formation of diverse 2‐amino‐1,4‐diazaheterocycles are described. Lewis acids (LAs) promote the reactions effectively, and chlorotrimethylsilane (TMSCl) has been found to be a promoter of choice. The scope and limitations of the reactions with regard to each of the components are evaluated and discussed. Post‐IMCR modifications of the synthesized heterocycles have been elaborated.