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The Potential Role of Cytokines in the Pathogenesis of Epstein-Barr Virus Associated Post-Transplant Lymphoproliferative Disease

1994; Taylor & Francis; Volume: 15; Issue: 5-6 Linguagem: Inglês

10.3109/10428199409049740

1042-8194

Parmjeet S. Randhawa, Anthony J. Demetris, Michael A. Nalesnik,

Eosinophilic Disorders and Syndromes

AbstractPost-transplant lymphoproliferative disease (PTLD) is a complication of Epstein-Barr vims infection occurring in immunosuppressed transplant recipients. Non-clonal lesions with a polymorphous histology have the potential of regressing, if the degree of immunosuppression is reduced, thereby giving the immune system a chance to recuperate. In contrast, clonal tumors with a monomorphous histology portend a bad clinical outcome. This review summarizes evidence that the biological behavior of PTLD may be predicated on intercellular interactions involving multiple cytokines. With further investigations to clarify the nature of these interactions, it should be possible to design rational strategies for the cytokine therapy of human PTLD.Key Words: Epstein-Barrpost-transplantlymphoproliferativecytokines