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Magnetic resonance spectroscopy as a measure of brain damage in multiple sclerosis

2005; Elsevier BV; Volume: 233; Issue: 1-2 Linguagem: Inglês

10.1016/j.jns.2005.03.018

1878-5883

Nicola De Stefano, M. Bartolozzi, Leonello Guidi, Maria Laura Stromillo, Antonio Federico,

Ultrasound and Hyperthermia Applications

Recent MR studies have emphasised the importance of neuronal and axonal damage in multiple sclerosis. In this respect, proton MR spectroscopy (by monitoring levels of N-acetylaspartate, a putative marker of axonal integrity) has been particularly illuminating by showing indirect evidence of neurodegeneration in both lesional and non-lesional brain tissues from the earliest stages of the disease. The importance of these changes to patients' clinical disability argues for the primary role of neuronal pathology in the pathogenesis of the disease.