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Pharmacological modulation of postprandial colonic motor activity in the pony

1987; Wiley; Volume: 10; Issue: 4 Linguagem: Inglês

10.1111/j.1365-2885.1987.tb00102.x

1365-2885

Thierry Roger, Y. Ruckebusch,

Respiratory and Cough-Related Research

Roger, T. & Ruckebusch, Y. Pharmacological modulation of postprandial colonic motor activity in the pony. J. vet. Pharmacol. Therap. 10, 273–282. The contractile activity of the equine large intestine exhibited a biphasic response to feeding: enhancement of migrating complexes passing along the colon and an increase of 50% in cyclic variations in smooth muscle at intervals of 20 min on the left ventral colon for a period of 5 to 7 h postfeeding. The cholinergic agonist, bethanechol (50 μg/kg subcutaneously), induced both the migrating complexes and the cyclic variations at intervals of 10–15 min. In contrast, the intra‐arterial infusion of PGF 2a (3 μg/kg/min) increased the contractile activity during infusion, but without inducing distinct patterns of activity. Atropine but not indomethacin or flunixin pre‐treatment prevented the effects of postprandial, cholinergic and PGF 2a stimulation of colonic motility, suggesting that the gastrocolonic reflex involved mainly cholinergic stimulation of the caecum and replicated colon, including the prostaglandin F 2a excitatory effects.