A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.
1992; Elsevier BV; Volume: 33; Issue: 21 Linguagem: Inglês
10.1016/s0040-4039(00)79572-4
ISSN1873-3581
AutoresRobin Polt, Yushun Li, Quintus Fernaǹdo, Mario Rivera,
Tópico(s)Sulfur Compounds in Biology
Resumomeso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.
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