Portal de Periódicos da CAPES

Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS

2000; Lippincott Williams & Wilkins; Volume: 54; Issue: 9 Linguagem: Inglês

10.1212/wnl.54.9.1859

1526-632X

Stephen L. Hauser, Jorge R. Oksenberg, Robin Lincoln, J. Garovoy, R. Beck, Stephen R. Cole, Pamela S. Moke, Kevin E. Kip, Robin L. Gal, Danielle Long,

Systemic Lupus Erythematosus Research

The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds of probable or definite MS at 5 years (odds ratio, 1.92; 95% confidence interval, 1.01 to 3.67; p = 0.04). The association was most apparent among patients with signal abnormalities on baseline brain MRI.