6‐Amino‐6‐deoxy‐5,6‐di‐ N ‐( N ′‐octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β‐Glucosidase
2009; Wiley; Volume: 10; Issue: 9 Linguagem: Inglês
10.1002/cbic.200900142
ISSN1439-7633
AutoresBoris Brumshtein, Matilde Aguilar‐Moncayo, M. Isabel García‐Moreno, Carmen Ortiz Mellet, José M. Garcı́a Fernández, Israel Silman, Yoseph Shaaltiel, David Aviezer, Joel L. Sussman, Anthony H. Futerman,
Tópico(s)Legume Nitrogen Fixing Symbiosis
ResumoAbstract 6‐Amino‐6‐deoxy‐5,6‐di‐ N ‐( N ′‐octyliminomethylidene)nojirimycin , a reducing analogue of N ‐nonyl‐1‐deoxynojirimycin, proved to be a potent and very selective inhibitor of β‐glucosidases, including human acid β‐glucosidase. Structural studies of the enzyme–inhibitor complex showed a binding mode in which the anomeric hydroxy group is accommodated in the “wrong” α configuration. magnified image
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