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BIBTEX RIS

Aberrant B-cell homeostasis in chronic GVHD

2015; Elsevier BV; Volume: 125; Issue: 11 Linguagem: Inglês

10.1182/blood-2014-12-567834

ISSN

1528-0020

Autores

Stefanie Sarantopoulos, Jerome Ritz,

Tópico(s)

Immunotherapy and Immune Responses

Resumo

Abstract Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival via B-cell activating factor and B-cell receptor–associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation.

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