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IL-7: A key regulator of B lymphopoiesis

2005; Elsevier BV; Volume: 18; Issue: 1 Linguagem: Inglês

10.1016/j.smim.2005.10.003

1096-3618

Craig D. Milne, Christopher J. Paige,

Immunotherapy and Immune Responses

Interleukin-7 plays important roles in the B cell developmental pathway including events leading to commitment, survival, proliferation, and maturation. Because of its central role in adult murine B lymphopoiesis, IL-7 is frequently used to generate B cell progenitors in vitro. We have shown that differentiation of IL-7-responsive cells in these cultures is influenced by CD45, pre-B cell receptor, and other downstream signaling molecules. A common, but often overlooked aspect of IL-7 containing cultures is the routine maturation of cells to the sIgM+ stage. The production of B cells in IL-7 containing cultures is balanced by cell death, since such cells fail to survive for long without additional stimulation.