Portal de Periódicos da CAPES

Rapid appearance of β-amyloid precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury

1991; Elsevier BV; Volume: 568; Issue: 1-2 Linguagem: Inglês

10.1016/0006-8993(91)91422-w

1872-6240

Naruhito Otsuka, Masanori Tomonaga, Kazuhiko Ikeda,

Neuroinflammation and Neurodegeneration Mechanisms

Brains of rats that had received needle stab wounds were examined sequentially for 72 h by immunohistochemistry using antibodies to β-amyloid precursor protein (APP). Immunoreactivity appeared 0.5 h after the injury in axons adjacent to the needle tract, becoming stronger over 15 h in neighboring swollen axons. APP-immunoreactive glial cells appeared 6 h after the injury around the needle tract and persisted throughout the experiment. Morphologically, these cells were thought to be mainly astrocytes.