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Longevity of the Placebo Effect in the Therapeutic Angiogenesis and Laser Myocardial Revascularization Trials in Patients With Coronary Heart Disease

2005; Elsevier BV; Volume: 95; Issue: 12 Linguagem: Inglês

10.1016/j.amjcard.2005.02.013

1879-1913

Jamal S. Rana, Arjuna P. Mannam, Laurel A. Donnell‐Fink, Ernesto V. Gervino, Frank W. Sellke, Roger J. Laham,

Angiogenesis and VEGF in Cancer

The long-term beneficial effects of placebo therapy were evaluated in angiogenesis and laser myocardial revascularization trials in patients who had end-stage coronary heart disease. Improvements in mean angina class, exercise treadmill time, and quality of life were mostly maintained at 30 ± 6 months of follow-up. Persistence of effect cannot be used as evidence of efficacy, and double-blinded trials are essential in this patient population. The long-term beneficial effects of placebo therapy were evaluated in angiogenesis and laser myocardial revascularization trials in patients who had end-stage coronary heart disease. Improvements in mean angina class, exercise treadmill time, and quality of life were mostly maintained at 30 ± 6 months of follow-up. Persistence of effect cannot be used as evidence of efficacy, and double-blinded trials are essential in this patient population.