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Gastric distribution and residence time of two anti-reflux formulations

1987; Elsevier BV; Volume: 39; Issue: 1-2 Linguagem: Inglês

10.1016/0378-5173(87)90212-2

1873-3476

Neena Washington, C. Washington, Clive Wilson,

Gastric Cancer Management and Outcomes

Two proprietary anti-reflux formulations “Liquid Gaviscon” and “Algicon Suspension” were characterized in vitro prior to an in vivo comparison in man. The raft strengths, pH profiles, time for raft formation and thickness of raft were measured over the normal gastric pH range. Ten ml of “Algicon” did not produce a raft in 125 ml hydrochloric acid below a concentration of 0.05 M. “Algicon” formed a weaker, thinner raft than “Gaviscon” in the in vitro tests, but there was no difference in speed of raft formation. “Gaviscon” produced a stronger raft than “Algicon” in the acid concentrations between 0.03 to 0.1 M hydrochloric acid. The standard Rossett and Rice test does not allow raft formation and partly releases antacid into the reaction mixture; “Algicon” (10 ml) maintained the pH above 3 for 23 min, but “Gaviscon” (10 ml) only raised the pH for 7 min. “Algicon” did not form a raft under the conditions of the experiment as described by Washington and coworkers (1986a) to measure the pH in and below the alginate raft. The gastric distribution and emptying were followed in 6 healthy female volunteers using gamma scintigraphy. Ten ml “Algicon” administered 30 min after a scrambled egg meal mixed and emptied with the meal, whereas the “Gaviscon” was found to empty significantly more slowly than the “Algicon” or food. Alginate and antacid therapy appear to be mutually incompatible in a single dose formulation.