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DNA repair: The Nijmegen breakage syndrome protein

1998; Elsevier BV; Volume: 8; Issue: 17 Linguagem: Inglês

10.1016/s0960-9822(98)70392-6

1879-0445

Carol Featherstone, Stephen P. Jackson,

Carcinogens and Genotoxicity Assessment

The gene mutated in Nijmegen breakage syndrome, a chromosome instability disorder, has been identified and sequenced. The protein product of this gene forms a complex with hMre11 and hRad50--proteins that are involved in repairing double-strand breaks in DNA.