Portal de Periódicos da CAPES

Defining early mycosis fungoides

2005; Elsevier BV; Volume: 53; Issue: 6 Linguagem: Inglês

10.1016/j.jaad.2005.08.057

1097-6787

Nicola Pimpinelli, Elise A. Olsen, Marco Santucci, Eric C. Vonderheid, A Haeffner, Seth R. Stevens, Guenter Burg, Lorenzo Cerroni, Brigitte Dréno, Earl J. Glusac, Joan Guitart, Peter Heald, Werner Kempf, Robert Knobler, Stuart R. Lessin, Christian A. Sander, Bruce R. Smoller, Gladys H. Telang, Sean Whittaker, Keiji Iwatsuki, Erik Obitz, Masahiro Takigawa, Maria L. Turner, Gary S. Wood,

T-cell and Retrovirus Studies

This editorial review summarizes the results of 5 meetings sponsored by the International Society for Cutaneous Lymphoma at which the clinicopathologic and ancillary features of early mycosis fungoides were critically examined. Based on this analysis, an algorithm was developed for the diagnosis of early mycosis fungoides involving a holistic integration of clinical, histopathologic, immunopathologic, and molecular biological characteristics. A novel aspect of this algorithm is that it relies on multiple types of criteria rather than just one, for example, histopathology. Before its finalization, the proposed diagnostic algorithm will require validation and possibly further refinement at multiple centers during the next several years. It is anticipated that a more standardized approach to the diagnosis of early mycosis fungoides will have a beneficial impact on the epidemiology, prognostication, treatment, and analysis of clinical trials pertaining to this most common type of cutaneous lymphoma. This editorial review summarizes the results of 5 meetings sponsored by the International Society for Cutaneous Lymphoma at which the clinicopathologic and ancillary features of early mycosis fungoides were critically examined. Based on this analysis, an algorithm was developed for the diagnosis of early mycosis fungoides involving a holistic integration of clinical, histopathologic, immunopathologic, and molecular biological characteristics. A novel aspect of this algorithm is that it relies on multiple types of criteria rather than just one, for example, histopathology. Before its finalization, the proposed diagnostic algorithm will require validation and possibly further refinement at multiple centers during the next several years. It is anticipated that a more standardized approach to the diagnosis of early mycosis fungoides will have a beneficial impact on the epidemiology, prognostication, treatment, and analysis of clinical trials pertaining to this most common type of cutaneous lymphoma.