Novel tetrahydropyrido[4,3-d]pyrimidines as gastric antilesion agents
1992; Elsevier BV; Volume: 27; Issue: 7 Linguagem: Inglês
10.1016/0223-5234(92)90085-f
ISSN1768-3254
AutoresP. J. SANFILIPPO, Maud Urbanski, L. Williams, J. Press, L. B. KATZ, D. A. SHRIVER, José A. Fernández, D. SHATYNSKI, S. J. OFFORD,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoA variety of substituted tetrahydropyrido[4,3-d]pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido[4,3-d]pyrimidines make them a potential alternative to prostaglandin therapy for gastric antilesion therapy and may have clinical utility in peptic ulcer disease.
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