Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

LPS from Escherichia coli protects against indomethacin-induced gastropathy in rats—Role of ATP-sensitive potassium channels

2006; Elsevier BV; Volume: 547; Issue: 1-3 Linguagem: Inglês

10.1016/j.ejphar.2006.07.028

1879-0712

Antoniella S. Gomes, Lívia M.F. Lima, Camila Linhares dos Santos, Fernando Q. Cunha, Ronaldo A. Ribeiro, Marcellus Henrique Loiola Ponte de Souza,

Cardiac Ischemia and Reperfusion

The effect of lipopolysaccharide (LPS) in gastric protection has not been elucidated, but ATP-sensitive potassium (KATP) channels are known to be involved in gastric defense. We evaluated the effect of LPS administration on indomethacin-induced gastropathy, and the role of KATP channels in this event. Rats received intravenous (i.v.) LPS administration. After 1/2, 6, 24 or 48 h, indomethacin was injected. 3 h later, gastric damage and myeloperoxidase activity were determined. Another group received LPS and 5 h later, glibenclamide, diazoxide or glibenclamide plus diazoxide. After 1 h, the rats received indomethacin and 3 h later, gastric damage and myeloperoxidase activity were evaluated. LPS reduced dose dependently gastric damage and myeloperoxidase activity induced by indomethacin. Glibenclamide reversed this LPS effect on indomethacin-induced gastropathy. Glibenclamide plus diazoxide administration did not change this LPS effect. Thus LPS has a protective effect against indomethacin-induced gastropathy, probably through activation of KATP channels.