Membrane potential and Donnan potential
1988; Elsevier BV; Volume: 29; Issue: 3 Linguagem: Inglês
10.1016/0301-4622(88)85049-x
ISSN1873-4200
AutoresHiroyuki Ohshima, Tamotsu Kondo,
Tópico(s)Neural Networks and Applications
ResumoThe Nernst-Planck-Poisson equations for the potential profile across a membrane are exactly solved without recourse to the assumption of constant field within the membrane. It is assumed that the membrane core of thickness dc is covered by a surface layer of thickness ds in which the membrane-fixed charges are distributed at a uniform density N. The membrane boundary potentials as well as the diffusion potentials contribute to the membrane potential. It is shown that for ds ≳ /k, k being the Debye-Hückel parameter, the potential in the membrane surface layer except in the region very near the membrane/solution boundary is effectively equal to the Donnan potential and that its contribution to the membrane potential becomes dominant as N increases. For low N, on the other hand, the membrane potential arises mostly from the diffusion potential.
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