Water-soluble polysaccharides from Salvia officinalis L. possessing immunomodulatory activity
2004; Elsevier BV; Volume: 65; Issue: 13 Linguagem: Inglês
10.1016/j.phytochem.2004.05.020
ISSN1873-3700
Autores Tópico(s)Phytochemical Studies and Bioactivities
ResumoA water-soluble polysaccharide complex (A) composed of galactose (17.9%), 3-O-methyl-galactose (3.0%), glucose (15.5%), mannose (8.3%), arabinose (30.4%), xylose (7.6%), fucose (2.6%), rhamnose (6.7%), and uronic acids (8.0%) has been isolated from the aerial parts of sage (Salvia officinalis L.) by cold water extraction. It showed a broad molecular-mass distribution pattern (Mw∼2000–93000) with a predominance of polymers with Mw<10000. Ion-exchange chromatography of A afforded six polymeric fractions (A1–A6) in which arabinogalactans associated with galacturonan and/or rhamnogalacturonan backbones prevail. Sage polysaccharides were examined for their immunomodulatory activity in the comitogenic thymocyte test which is interpreted as being an in vitro correlate of adjuvant activity. The acidic polysaccharide fractions A2, A3 and A4 exhibited the highest mitogenic and comitogenic activities of all fractions tested, and relatively high SIcomit/SImit ratios ∼3 indicate potential adjuvant properties of these polysaccharides.
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