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Halo giant congenital melanocytic nevus: In vitro immunologic studies

1988; Elsevier BV; Volume: 19; Issue: 5 Linguagem: Inglês

10.1016/s0190-9622(88)70258-3

1097-6787

Brian Berman, Annette M. Shaieb, Dennis S. France, Douglas D. Altchek,

CAR-T cell therapy research

We have assessed in vitro humoral and cell-mediated immune reactions of a patient with a giant congenital melanocytic nevus that showed clinical and histologic evidence of spontaneous regression. Nevus cell-specific antibody was detected in the patient's serum, which was cytotoxic to epidermal cells isolated from the pigmented nevus and specifically to cells of a human melanoma line in a complement-dependent fashion. The presence of epidermal Langerhans cells, known to be antigen-presenting cells, was required for nevus cell-specific activation of the patient's T lymphocytes. Antibody-independent inhibition of melanoma cell growth was detected by the use of the patient's mononuclear cells. Therefore both humoral and cell-mediated immunity may be involved in nevus cell rejection and halo formation.