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Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant Plasmodium falciparum

1989; American Association for the Advancement of Science; Volume: 244; Issue: 4909 Linguagem: Inglês

10.1126/science.2658061

1095-9203

Craig M. Wilson, Adelfa E. Serrano, Annemarie Wasley, Michael P. Bogenschutz, Anuraj H. Shankar, Dyann F. Wirth,

Drug Transport and Resistance Mechanisms

The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.