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Clinical Potential for the Use of Neuroprotective Agents. A Brief Overview

1995; Wiley; Volume: 765; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1995.tb16554.x

1749-6632

B. Stuart Trembly,

Intraocular Surgery and Lenses

Annals of the New York Academy of SciencesVolume 765, Issue 1 p. 1-20 Clinical Potential for the Use of Neuroprotective Agents. A Brief Overview BRUCE TREMBLY, BRUCE TREMBLY Section of Neurosurgery VA Medical Center Togus, Maine 04330Search for more papers by this author BRUCE TREMBLY, BRUCE TREMBLY Section of Neurosurgery VA Medical Center Togus, Maine 04330Search for more papers by this author First published: September 1995 https://doi.org/10.1111/j.1749-6632.1995.tb16554.xCitations: 11AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Ginsberg, M. D. & W. A. Pulsinelli. 1994. The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke (editorial). Ann. Neurol. 36: 553–554. 2 Scheinberg. 1994. Stroke: the way things really are. Stroke 25: 1290–1294. 3 Fisher, M. & J. Bogousslavsky. 1993. Evolving toward effective therapy for acute ischemic stroke. JAMA 270: 360–364. 4 Wright, R. H. & A. Ames, III. 1964. Measurement of maximal permissable cerebral ischemia and a study of its pharmacological prolongation. J. Neurosurg. 7: 567–574. 5 Olney, J. W., L. Labruyere, G. Wang, D. F. Wozniak, M. T. Price & M. A. Sesma. 1991. NMDA antagonist neurotoxicity: Mechanism and prevention. Science 254: 1515–1518. 6 The American Nimodipine Study Group. 1992. Clinical trial of nimodipine in acute ischemic stroke. Stroke 23: 3–8. 7 Kaste, M., R. Fogelholm, T. Erila, H. Palomaki, K. Murros, A. Rissanen & S. Sarna. 1994. A randomized, double-blind, placebo-controlled trial of nimodipine in acute ischemic hemispheric stroke. Stroke 25: 1348–1353. 8 Barsan, W. G., T. G. Brott, J. P. Broderick, E. C. Haley, D. E. Levy & J. R. Marler. 1993. Time of hospital presentation in patients with acute stroke. Arch. Int. Med. 153: 2558–2561. 9 Gomez, C. R., M. D. Malkoff, C. M. Sauer, R. Tulyapronchote, C. M. Burch & G. A. Banet. 1994. Code stroke. An attempt to shorten inhospital therapeutic delays. Stroke 25: 1920–1923. 10 Camarata, P. J., R. C. Heros & R. E. Latchaw. 1994. “Brain Attack”: the rationale for treating stroke as a medical emergency. Neurosurgery 34: 144–158. 11 Siesjo, B. K. 1988. Historical overview. Calcium, ischemia and death of brain cells. Ann. N.Y. Acad. Sci. 522: 638–661. 12 Cheung, J. Y., J. V. Bonventre, C. D. Malis & A. Leaf. 1986. Calcium and ischemic injury. N. Engl. J. Med. 314: 1670–1676. 13 Busto, R., W. D. Dietrich, M. Y-T. Globus, I. Valdes, P. Scheinberg, & M. D. Ginsberg. 1987. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J. Cereb. Blood Flow Metab. 7: 729–738. 14 Minamisawa, H., P. Mellergard, M-L. Smith, F. Bengtsson, S. Theander, F. Boris-Moller & B. K. Siesio. 1990. Preservation of brain temperature during ischemia in rats. Stroke 21: 758–764. 15 Chumas, P., M. R. Del Bigio, J. M. Drake & U. I. Tuor. 1993. A comparison of the protective effects of dexamethasone to other potential prophylactic agents in a neonatal rat model of cerebral hypoxia-ischemia. J. Neurosurg. 79: 414–420. 16 Hall, E. D. 1992. The neuroprotective pharmacology of methylprednisolone. J. Neurosurg. 76: 13–22. 17 Hall, E. D. 1993. Lipid antioxidants in acute central nervous system injury. Ann. Emerg. Med. 22: 1022–1027. 18 Bullock, R., D. I. Graham, S. Swanson & J. McCulloch. 1994. Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerbral ischemia in the cat. J. Cereb. Flow Metab. 14: 466–471. 19 Buchan, A. M., H. Lesiuk, K. A. Barnes, H. Li, Z-G. Huang, K. E. Smith & D. Xue. 1993. Ampa antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists Stroke 24(Suppl. 1): I-148–1–152. 20 Bullock, R. & H. Fujisawa. 1992. The role of glutamate antagonists for the treatment of CNS injury. J. Neurotrauma 9(Suppl. 2): S443–S462. 21 Choi, D. W. 1989. Toward a new pharmacology of ischemic neuronal death. In Selective Vulnerability of the Brain: New Insights into the Pathophysiology of Stroke. R. C. Collins, Moderator. Ann. Intern. Med. 110: 992–1000. 22 The Dextrorphan Study Group & Hoffman-La Roche. 1995. Safety, tolerability and pharmacokinetics of the N-methyl-d-aspartate antagonist, RO–01–6794/706 in patients with acute ischemic stroke. Ann. N. Y. Acad. Sci. This volume. 23 Bullock, R., A. Kotake & H. Faleck. 1995. Strategies for neuroprotection with glutamate antagonists: extrapolating from evidence taken from the first stroke and head injury studies. Ann. N. Y. Acad. Sci. This volume. 24 Muir, K. W., D. G. Grosset & K. R. Lees. 1995. Clinical pharmacology of CNS 1102 in volunteers. Ann. N. Y. Acad. Sci. This volume. 25 Palmer, G. C., E. F. Cregan, A. R. Borrelli & F. Willet. 1995. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann. N. Y. Acad. Sci. This volume. 26 Lyden, P. D. & L. Lonzo. 1994. Combination therapy protects ischemic brain in rats. Stroke 25: 189–196. 27 Traystman, R. J. 1994. Editorial comment. Stroke 25: 196. 28 The Ancrod Stroke Study Investigators. 1994. Ancrod for the treatment of acute ischemic brain infarction. Stroke 25: 1755–1759. 29 Jonas, S. 1995. Prophylactic pharmacologic neuroprotection against focal cerebral ischemia. Ann. N. Y. Acad. Sci. This volume. 30 Spencer, M. P., G. I. Thomas, S. C. Nicholls & L. R. Sauvage. 1990. Detection of middle cerebral artery emboli during carotid endarterectomy using transcranial Doppler ultrasonography. Stroke 21: 415–423. 31 Naylor, A. R., J. A. W. Wildsmith, J. McClure, A. McL. Jenkins & C. V. Ruckley. 1991. Transcranial Doppler monitoring during carotid endarterectomy Br. J. Surg. 78: 1264–1268. 32 Habozit, B. 1990. The silent brain infarct before and after carotid surgery. Ann. Vase. Surg. 4: 485–489. 33 Bullock, R. 1994. Personal communication, letter dated November 9, 1994. 34 Fisher, M., S. Jonas & R. L. Sacco. 1994. Prophylactic neuroprotection for cerebral ischemia. Stroke. 25: 1075–1080. 35 Allen, G. S. et al. 1983. Cerebral arterial spasm: a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N. Engl. J. Med. 308: 616–624. 36 Handa, J., M. Matsuda, Y. Nakasu, S. Nakasu, M. Kidooka & K. Watanabe. 1984. Early operation of aneurysmal subarachnoid hemorrhage. Use of nicardipine, a calcium channel blocker. Arch. Jpn. Chir. 53: 619–630. 37 Picard, J. D., G. D. Murray, R. Illingworth, M. D. M. Shaw, G. M. Teasdale, P. M. Foy, P. R. D. Humphrey, D. A. Lang, R. Nelson, P. Richards, J. Sinar, S. Bailey & A. Skene. 1989. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. Br. Med. J. 298: 636–642. 38 Haley, E. C., Jr., N. F. Kassell, J. C. Torner & the participants. 1993. A randomized trial of nicardipine in subarachnoid hemorrhage: angiographic and transcranial Doppler ultrasound results. A report of the Cooperative Aneurysm Study. J. Neurosurg. 78: 548–553. 39 Haley, E. C., Jr., N. F. Kassell, J. C. Torner & the participants. 1993. A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoidal hemorrhage. A report of the Cooperative Aneurysm Study. J. Neurosurg. 78: 537–547. 40 Kanamaru, K., B. K. A. Weir, I. Simpson, T. Witbeck & M. Grace. 1991. Effect of 21-aminosteroid U-74006F on lipid perioxidation in subarachnoid clot. J. Neurosurg. 74: 454–459. 41 Bullock, R., A. Zauner, J. S. Myseros, A. Marmarou, J. J. Woodward & H. F. Young. 1995. Evidence for prolonged release of excitatory amino acids in severe human head trauma: relationship to clinical events. Ann. N. Y. Acad. Sci. This volume. 42 Olney, J. W. 1982. The toxic effects of glutamate and related compounds in the retina and the brain. Retina 2: 341–358. 43 Olney, J. W. 1990. Excitotoxin-mediated neuron death in youth and old age. Prog. Brain Res. 86: 37–51. 44 Myseros, J. S. & R. Bullock. 1995. The rationale for glutamate antagonists in the treatment of traumatic brain injury. Ann. N. Y. Acad. Sci. This volume. 45 Bullock, R. 1993. Opportunities for neuroprotective drugs in clinical management of head injury. J. Emerg. Med. 11: 23–30. 46 Buchan, A. & W. A. Pulsinelli. 1990. Hypothermia but not the N-methyl-d-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J. Neurosci. 10: 311–316. 47 Bowyer, J. F. 1995. The role of hyperthermia in amphetamine's interaction with NMDA receptors, nitric oxide and age to produce neurotoxicity (Abstr.). Ann. N. Y. Acad. Sci. This volume. 48 Palmer, A. M., D. W. Marion, M. I. Botscheller & E. E. Redd. 1993. Therapeutic hypothermia is cytoprotective without attenuating the traumatic brain injury-induced elevations in interstitial concentrations of aspartate and glutamate. J. Neurotrauma 10: 363–372. 49 Busto, R., M. Y-T. Globus, W. D. Diftrich, E. Martinez, I. Valdes & M. D. Ginsberg. 1989. Effect of mild hypothermia in ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 20: 904–910. 50 Hall, E. D., P. K. Andrus & K. E. Pazara. 1993. Protective efficacy of a hypothermic pharmacological agent in gerbil forebrain ischemia. Stroke 24: 711–715. 51 Karibe, H., J. Chen, G. J. Zarow, S. H. Graham & P. R. Weinstein. 1994. Delayed induction of mild hypothermia to reduce infarct volume after temporary middle cerebral artery occlusion in rats. J. Neurosurg. 80: 112–119. 52 Sternau, L., C. Thompson, W. D. Dietrich, R. Busto, M. Y-T. Globus & M. D. Ginsberg. 1991. Intracranial temperature observations in the human brain. J. Cereb. Blood Flow Metab. 11(Suppl. 2): S123. 53 Fay, T. 1943. Observations on generalized refrigeration in cases of severe cerebral trauma. Assoc. Res. Nerv. Ment. Dis. Proc. 24: 611–619. 54 Drake, C. G., H. W. K. Barr, J. C. Coles & N. F. Gergely. 1964. The use of extracorporeal circulation and profound hypothermia in the treatment of ruptured intracranial aneurysm. J. Neurosurg. 21: 575–581. 55 Clifton, G. L., J. Y. Jiang, B. G. Lyeth, L. W. Jenkins, R. J. Hamm & R. L. Hayes. 1991. Marked protection by moderate hypothermia after experimental traumatic brain injury. J. Cereb. Blood Flow Metab. 11: 114–121. 56 Dietrich, W. D. 1992. The importance of brain temperature in cerebral injury. J. Neurotrauma 9(Suppl. 2): S475–S485. 57 Tator, C. H. & M. G. Fehlings. 1991. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J. Neurosurg. 75: 15–26. 58 Bracken, M. B. et al. 1992. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the Second National Acute Spinal Cord Injury Study. J. Neurosurg. 76: 23–31. 59 Ducker, T. B. & S. M. Zeidman. 1994. Spinal cord injury. Role of steroid therapy. Spine 19: 2281–2287. 60 Galandiuk, S., G. Raque, S. Appel & H. C. Polk, Jr. 1993. The two-edged sword of large-dose steroids for spinal cord trauma. Ann. Surg. 218: 419–427. 61 Hall, E. D. & J. M. Braughler. 1982. Effects of intravenous methylprednisolone on spinal cord lipid perioxidation and (Na++ K+)-ATPase activity. J. Neurosurg. 57: 247–253. 62 Hall, E. D., M. Braugher & J. M. McCall. 1992. Antioxidant effects in brain and spinal cord injury. J. Neurotrauma. 9(Suppl. 1): S165–S172. 63 Guha, A., C. H. Tator & I. Piper. 1985. Increase in rat spinal cord blood flow with the calcium channel blocker, nimodipine. J. Neurosurg. 63: 250–259. 64 Guha, A., C. H. Tator & I. Piper. 1987. Effect of a calcium channel blocker on posttraumatic spinal cord blood flow. J. Neurosurg. 66: 423–430. 65 Black, P., R. S. Markowitz, S. D. Finkelstein, K. McMonagle-Strucko & J. A. Gillespie. 1988. Experimental spinal cord injury: Effect of a calcium channel antagonist (nicardipine). Neurosurgery 22: 61–66. 66 Marsala, M., I. Vanicky & T. L. Yaksh. 1994. Effect of graded hypothermia (27°C to 34°C) on behavioral function, histopathology, and spinal blood flow after spinal ischemia in rat. Stroke 25: 2038–2046. 67 Collins, W. F. 1993. Discussion in Galandiuk et al.60. 68 Andrews, R. J. & J. R. Bringas. 1993. A review of brain retraction and recommendations for minimizing intraoperative brain injury. Neurosurgery 33: 1052–1064. 69 Andrews, R. J., J. R. Bringas & R. P. Muto. 1993. Effects of mannitol on cerebral blood flow, blood pressure, blood viscosity, hematocrit, sodium and potassium. Surg. Neurol. 39: 218–222. 70 Andrews, R. J. & R. P. Muto. 1992. Retraction brain ischemia: mannitol plus nimodipine preserves both cerebral blood flow and evoked potentials during normoventilation and hyperventilation. Neurol Res. 14: 19–25. 71 Andrews, R. J. & R. P. Muto. 1992. Retraction brain ischemia: cerebral blood flow, evoked potentials, hypotension and hyperventilation in a new animal model. Neurol. Res. 14: 12–18. 72 Betz, A. L. & H. C. Coester. 1990. Effect of steroids on edema and sodium uptake of the brain during focal ischemia in rats. Stroke 21: 1119–1204. 73 Tizzano, J. P., K. I. Griffey & D. D. Schoepp. 1995. Receptor subtypes linked to metabotropic receptor agonist mediated limbic seizures in mice. Ann. N. Y. Acad. Sci. This volume. 74 Mervis, R. F., N. Kuntz, D. Burton, R. Dvorak, R. Tandon, L. Hoover, M. S. Wood & P. R. Soloman. 1995. Structural-functional correlates of neuroprotection in the aging rabbit by a calcium channel blocker: nimodipine reverses neocortical dendritic atrophy and improves memory retention (Abstr.) Ann. N. Y. Acad. Sci. This volume. 75 Kowalska, M. & J. F. Disterhoft. 1994. Relation of nimodipine dose and serum concentration to learning enhancement in aging rabbits. Exp. Neurol. 127: 159–166. 76 Herning, R. I., X. Guo & W. R. Lange. 1995. The effects of nimodipine on the EEG of substance abusers. Ann. N. Y. Acad. Sci. This volume. 77 Parnetti, L., U. Senin, M. Carosi, H. Baasch and the Nimodipine Study Group. 1993. Mental deterioration in old age: results of two multicenter, clinical trials with nimodipine. Clin. Ther. 15: 394–406. 78 Tollefson, G. D. 1990. Short-term effects of the calcium channel blocker nimodipine (Bae-e-9736) in the management of primary degenerative dementia. Biol. Psychiatry 27: 1133–1142. 79 Greenamyre, J. T., R. V. Eller, Z. Zhang, A. Ovadia, R. Kurlan & D. M. Gash. 1994. Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease. Ann. Neurol. 35: 655–661. 80 Greenberg, D. A. 1994. Glutamate and Parkinson's disease. Ann. Neurol. 35: 639. 81 Olney, J. W., C. F. Zorumski, G. R. Stewart, M. T. Price, G. Wang & J. Labruyere. 1990. Excitotoxicity of -dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases. Exp. Neurol. 108: 269–272. 82 Herning, R. I., X. Guo & W. R. Lange. 1995. Nimodipine improves information processing in substance abusers. Ann. N. Y. Acad. Sci. This volume. 83 Jackson, D. L., J. D. Richardson & K. M. Hargreaves. 1994. Peripheral administration of excitatory amino acids modulates nociceptive behavior in rats. Soc. Neurosci. (Abstr.) 20(part 2): 1390. 84 Schwartzman, R. J. 1993. Reflex sympathetic dystrophy. Curr. Opin. Neurol. Neurosurg. 6: 531–536. 85 Bartus, R. T., K. L. Baker, A. D. Heiser, S. D. Sawyer, R. L. Dean, P. J. Elliott & J. A. Straub. 1994. Post-ischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J. Cereb. Blood Flow Metab. 14: 537–544. 86 Bartus, R. T., N. J. Hayward, P. J. Elliott, S. D. Sawyer, K. L. Baker, R. L. Dean, A. Akiyama, J. A. Straub, S. L. Harbison, Z. Li & J. Powers. 1994. Calpain inhibitor AK295 protects neurones from focal brain ischemia. Effects of postocclusion intra-arterial administration. Stroke 25: 2265–2270. 87 Hong, S-C., Y. Goto, G. Lanzino, S. Soleau, N. F. Kassell & K. S. Lee. 1994. Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia. Stroke 25: 663–669. Citing Literature Volume765, Issue1Neuroprotective Agents: Clinical and Experimental AspectsSeptember 1995Pages 1-20 ReferencesRelatedInformation