Enzymatic Preparation of Novel Aminoalkylpyridines using Lipases in Organic Solvents
2007; Wiley; Volume: 349; Issue: 8-9 Linguagem: Inglês
10.1002/adsc.200600634
ISSN1615-4169
AutoresOliver Torre, E. Nebot, Vicente Gotor‐Fernández, Vicente Gotor,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoAbstract A wide range of novel, enantiomerically pure 4‐chloro(amino)pyridine derivatives has been synthesised through a chemoenzymatic approach, Candida antarctica lipase B (CAL‐B) and Pseudomonas cepacia lipase (PSL) being found to be excellent biocatalysts for the preparation of new and interesting amines and amides in enantiomerically pure form through enzymatic aminolysis reactions. A study of the enzymatic reactivity of CAL‐B and PSL has been done in the resolution of a library of amine structures in an attempt to rationalise the experimental results obtained in their enzymatic kinetic resolution mediated by lipases.
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