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BIBTEX RIS

Influence of Haemophilus influenzae β-lactamase production and/or ftsI gene mutations on in vitro activity of and susceptibility rates to aminopenicillins and second- and third-generation cephalosporins

2007; Elsevier BV; Volume: 30; Issue: 2 Linguagem: Inglês

10.1016/j.ijantimicag.2007.02.014

ISSN

1872-7913

Autores

Juan García-de-Lomas, M. Lerma, Laura Cebrián, J.L. Juan-Bañón, Pilar Coronel, María-José Giménez, L. Aguilar,

Tópico(s)

Antibiotic Resistance in Bacteria

Resumo

Nineteen β-lactamase–negative ampicillin-resistant (BLNAR) and 2 β-lactamase–positive amoxicillin-clavulanic acid–resistant Canadian Haemophilus influenzae strains were characterized. All 21 isolates were found to have the N526K mutations in their ftsI genes, and their ampicillin MIC50 values were 4–8 times that of β-lactamase–negative ampicillin-susceptible strains. The difficulty in detection of BLNAR strains was discussed.

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