Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage
2000; Elsevier BV; Volume: 71; Linguagem: Inglês
10.1016/s0367-326x(00)00188-x
ISSN1873-6971
AutoresRaffaele Capasso, Lorraine Aparecida Pinto, Maria Luisa Vuotto, Giulia Di Carlo,
Tópico(s)Helicobacter pylori-related gastroenterology studies
ResumoThis study examines the anti-ulcerogenic activity of eugenol, a natural compound obtained from many natural sources. Gastric ulcers, induced by administration of two ulcerogenic agents, i.e. platelet activating factor (PAF) and ethanol, were dose-dependently and significantly reduced by eugenol (10-100 mg/kg, p.o.) pre-treatment. Eugenol was able to reduce not only the number of ulcers but also the gravity of lesions.
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