Produção Nacional
Revisado por pares
Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
2002; Brazilian Society of Tropical Medicine; Volume: 35; Issue: 2 Linguagem: Inglês
10.1590/s0037-86822002000200001
ISSN1678-9849
AutoresWilson Mayrink, Gilmara Cristina dos Santos, Vicente de Paulo Coelho Peixoto de Toledo, Tânia Mara Pinto Dabés Guimarães, George Luiz Lins Machado-Coelho, Odair Genaro, Carlos Alberto da Costa,
Tópico(s)Trypanosoma species research and implications
ResumoAntigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin(R) and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.
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