Portal de Periódicos da CAPES

Depression in methadone maintenance treatment patients: Rate and risk factors

2006; Elsevier BV; Volume: 99; Issue: 1-3 Linguagem: Inglês

10.1016/j.jad.2006.09.017

1573-2517

Einat Peles, Shaul Schreiber, Yosef Naumovsky, Miriam Adelson,

Prenatal Substance Exposure Effects

Depression is widely prevalent among former heroin addicts in methadone maintenance treatment (MMT). The risk factors for depression among MMT patients that have not been well characterized, was studied.In a cross-sectional study (January, 2004-August, 2005), 90 MMT patients were evaluated for depression by the 21-item Hamilton Rating Scale for Depression (21-HAM-D) and the Brief Psychiatric Rating scale (BPRS). To study possible induction of depression by drug abuse, urine samples tested for opiates, cocaine metabolite (benzoylecgonine), benzodiazepines (BDZ), cannabis (THC), amphetamines and methadone metabolite during 1 month preceding study entry: a drug was defined as being positive if at least one sample was positive.The 21-HAM-D and BPRS scores were significantly correlated (Pearson R=0.76, p or = 18). Fifteen new patients in MMT had better scores (5.1+/-5.7) than continuous patients (17.7+/-6.2, p<0.0005), independent of treatment duration. Higher scores were in 51 patients with any Axis I psychiatric diagnosis (18.9+/-5.7 vs. 11.4+/-7.9, p 120 mg/day.