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Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia

2013; National Academy of Sciences; Volume: 110; Issue: 46 Linguagem: Inglês

10.1073/pnas.1318257110

1091-6490

Roberto Tamma, Li Sun, Concetta Cuscito, Ping Lü, Michelangelo Corcelli, Jianhua Li, Graziana Colaianni, Surinder S. Moonga, Adriana Di Benedetto, Maria Grano, Silvia Colucci, Tony Yuen, Maria I. New, Alberta Zallone, Mone Zaidi,

Anesthesia and Neurotoxicity Research

Significance In this study, we show that a primitive brain hormone, arginine vasopressin (AVP), which has hitherto been implicated in regulating water balance in mammals, has a function in skeletal homeostasis. Using genetically modified mice that are lacking one of the AVP receptors as well as pharmacologic inhibitors, we show that AVP negatively regulates osteoblasts (cells that form new bone) and stimulates osteoclasts (cells that remove old bone). Our findings explain the bone loss that is known to accompany low blood sodium levels in patients when AVP levels are high.