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Constituintes químicos e avaliação do potencial antiinflamatório e antioxidante de extratos das folhas de Chomelia obtusa Cham. & Schltdl. (Rubiaceae)

2008; Brazilian Chemical Society; Volume: 31; Issue: 8 Linguagem: Inglês

10.1590/s0100-40422008000800013

1678-7064

Michely Pereira de Barros, Silvana Maria de Oliveira Santin, Willian Ferreira da Costa, Gentil J. Vidotti, María Helena Sarragiotto, Maria Conceição de Souza, Ciomar Aparecida Bersani-Amado,

Agricultural and Food Sciences

Chomelia obtusa CHAM.& SCHLTDL.(RUBIACEAE).The phytochemical investigation of Chomelia obtusa leaves led to the isolation of four triterpenes (3-O-β-D-quinovopyranosyl-28-O-β-D-glycopyranosyl quinovic acid, 3-O-β-Dquinovopyranosyl-28-O-β-D-glycopyranosyl cincholic acid, and a mixture of ursolic and oleanolic acids), two flavonoids (3-O-β-Dglycopyranosyl quercetin, 3-O-[α-L-rhamnopyranosyl-( 1→6)-β-D-galactopyranoside] quercetin), besides bornesitol and a mixture of 3,5-and 4,5-O-dicaffeoyl quinic acids.The structures of the isolated compounds were assigned on the basis of spectroscopic data, including two-dimensional NMR methods.The anti-inflammatory and antioxidant activities of the crude methanolic extract and of its fractions were evaluated.This is the first report on the chemical and biological investigation of the Chomelia genus.