Artigo Acesso aberto Revisado por pares

Association between the NAT1 1095C > A polymorphism and homocysteine concentration

2006; Wiley; Volume: 140A; Issue: 21 Linguagem: Inglês

10.1002/ajmg.a.31475

ISSN

1552-4833

Autores

Anna Stanisławska‐Sachadyn, Liselotte E. Jensen, Carmel Kealey, Jayne V. Woodside, Ian Young, John M. Scott, Liam Murray, Colin Boreham, Helene McNulty, JJ Strain, Alexander S. Whitehead,

Tópico(s)

Acute Lymphoblastic Leukemia research

Resumo

American Journal of Medical Genetics Part AVolume 140A, Issue 21 p. 2374-2377 Research Letter Association between the NAT1 1095C > A polymorphism and homocysteine concentration† Anna Stanisławska-Sachadyn, Anna Stanisławska-Sachadyn Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PennsylvaniaSearch for more papers by this authorLiselotte E. Jensen, Liselotte E. Jensen Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PennsylvaniaSearch for more papers by this authorCarmel Kealey, Carmel Kealey Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PennsylvaniaSearch for more papers by this authorJayne V. Woodside, Jayne V. Woodside Cardiovascular Research Centre, Queen's University Belfast, Belfast, Northern Ireland, United KingdomSearch for more papers by this authorIan S. Young, Ian S. Young Cardiovascular Research Centre, Queen's University Belfast, Belfast, Northern Ireland, United KingdomSearch for more papers by this authorJohn M. Scott, John M. Scott Department of Clinical Medicine, Trinity College, Dublin, IrelandSearch for more papers by this authorLiam Murray, Liam Murray Cardiovascular Research Centre, Queen's University Belfast, Belfast, Northern Ireland, United KingdomSearch for more papers by this authorColin A. Boreham, Colin A. Boreham Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United KingdomSearch for more papers by this authorHelene McNulty, Helene McNulty Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United KingdomSearch for more papers by this authorJ.J. Strain, J.J. Strain Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United KingdomSearch for more papers by this authorAlexander S. Whitehead, Corresponding Author Alexander S. Whitehead [email protected] Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PennsylvaniaDepartment of Pharmacology, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104-6084.Search for more papers by this author Anna Stanisławska-Sachadyn, Anna Stanisławska-Sachadyn Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PennsylvaniaSearch for more papers by this authorLiselotte E. Jensen, Liselotte E. Jensen Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PennsylvaniaSearch for more papers by this authorCarmel Kealey, Carmel Kealey Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PennsylvaniaSearch for more papers by this authorJayne V. Woodside, Jayne V. Woodside Cardiovascular Research Centre, Queen's University Belfast, Belfast, Northern Ireland, United KingdomSearch for more papers by this authorIan S. Young, Ian S. Young Cardiovascular Research Centre, Queen's University Belfast, Belfast, Northern Ireland, United KingdomSearch for more papers by this authorJohn M. Scott, John M. Scott Department of Clinical Medicine, Trinity College, Dublin, IrelandSearch for more papers by this authorLiam Murray, Liam Murray Cardiovascular Research Centre, Queen's University Belfast, Belfast, Northern Ireland, United KingdomSearch for more papers by this authorColin A. Boreham, Colin A. Boreham Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United KingdomSearch for more papers by this authorHelene McNulty, Helene McNulty Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United KingdomSearch for more papers by this authorJ.J. Strain, J.J. Strain Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United KingdomSearch for more papers by this authorAlexander S. Whitehead, Corresponding Author Alexander S. Whitehead [email protected] Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PennsylvaniaDepartment of Pharmacology, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104-6084.Search for more papers by this author First published: 11 October 2006 https://doi.org/10.1002/ajmg.a.31475Citations: 5 † How to cite this article: Stanisławska-Sachadyn A, Jensen LE, Kealey C, Woodside JV, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS. 2006. Association between the NAT1 1095C > A polymorphism and homocysteine concentration. Am J Med Genet Part A 140A:2374–2377. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Badawi AF, Hirvonen A, Bell DA, Lang NP, Kadlubar FF. 1995. Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder. Cancer Res 55: 5230–5237. Bell DA, Badawi AF, Lang NP, Ilett KF, Kadlubar FF, Hirvonen A. 1995. Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: Association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. Cancer Res 55: 5226–5229. Boreham CA, Twisk J, Savage MJ, Cran GW, Strain JJ. 1997. Physical activity, sports participation, and risk factors in adolescents. Med Sci Sports Exercise 29: 788–793. Boreham C, Twisk J, van Mechelen W, Savage M, Strain J, Cran G. 1999. Relationships between the development of biological risk factors for coronary heart disease and lifestyle parameters during adolescence: The Northern Ireland Young Hearts Project. Public Health 113: 7–12. Brockton N, Little J, Sharp L, Cotton SC. 2000. N-acetyltransferase polymorphisms and colorectal cancer: A HuGE review. Am J Epidemiol 151: 846–861. Brown KS, Kluijtmans LA, Young IS, Murray L, McMaster D, Woodside JV, Yarnell JW, Boreham CA, McNulty H, Strain JJ, McPartlin J, Scott JM, Mitchell LE, Whitehead AS. 2004. The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine. Atherosclerosis 174: 315–322. Grant DM, Hughes NC, Janezic SA, Goodfellow GH, Chen HJ, Gaedigk A, Yu VL, Grewal R. 1997. Human acetyltransferase polymorphisms. Mutat Res 376: 61–70. Hein DW. 2002. Molecular genetics and function of NAT1 and NAT2: Role in aromatic amine metabolism and carcinogenesis. Mutat Res 506-507: 65–77. Hein DW, McQueen CA, Grant DM, Goodfellow GH, Kadlubar FF, Weber WW. 2000. Pharmacogenetics of the arylamine N-acetyltransferases: A symposium in honor of Wendell W. Weber. Drug Metab Dispos 28: 1425–1432. Jensen LE, Hoess K, Whitehead AS, Mitchell LE. 2005. The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida. Birth Defects Res A Clin Mol Teratol 73: 512–516. Kluijtmans LA, Young IS, Boreham CA, Murray L, McMaster D, McNulty H, Strain JJ, McPartlin J, Scott JM, Whitehead AS. 2003. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 101: 2483–2488. Lammer EJ, Shaw GM, Iovannisci DM, Finnell RH. 2004a. Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for orofacial clefts. Birth Defects Res 70: 846–852. Lammer EJ, Shaw GM, Iovannisci DM, Van Waes J, Finnell RH. 2004b. Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms. Epidemiology 15: 150–156. McDonald SD, Walker MC. 2001. Homocysteine levels in pregnant women who smoke cigarettes. Med Hypotheses 57: 792–796. Medina M, Urdiales JL, Amores-Sanchez MI. 2001. Roles of homocysteine in cell metabolism: Old and new functions. Eur J Biochem 268: 3871–3882. Mills JL, McPartlin JM, Kirke PN, Lee YJ, Conley MR, Weir DG, Scott JM. 1995. Homocysteine metabolism in pregnancies complicated by neural tube defects. Lancet 345: 149–151. Minchin RF. 1995. Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells. Biochem J 307: 1–3. Molloy AM, Scott JM. 1997. Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol 281: 43–53. Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, Ueland M, Kvale G. 1995. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 274: 1526–1533. Prescott NJ, Winter RM, Malcolm S. 2002. Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palate. J Med Genet 39: 368–369. Ubbink JB, Hayward Vermaak WJ, Bissbort S. 1991. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr 565: 441–446. Ward A, Summers MJ, Sim E. 1995. Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism. Biochem Pharmacol 49: 1759–1767. Yang M, Katoh T, Delongchamp R, Ozawa S, Kohshi K, Kawamoto T. 2000. Relationship between NAT1 genotype and phenotype in a Japanese population. Pharmacogenetics 10: 225–232. Citing Literature Volume140A, Issue211 November 2006Pages 2374-2377 ReferencesRelatedInformation

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