Representation of the constitutional and stereochemical features of chemical systems in the computer assisted design of syntheses
1974; Elsevier BV; Volume: 30; Issue: 13 Linguagem: Inglês
10.1016/s0040-4020(01)97318-1
ISSN1464-5416
AutoresJohn T. Blair, Johann Gasteiger, Carol Gillespie, Paul Gillespie, Ivar Ugi,
Tópico(s)History and advancements in chemistry
ResumoAn artificial intelligence designed SCH 47949 synthesis is achieved in a stereoselective manner. The key step contains a stereoselective one-pot construction of the trans β-lactam framework via thermal electrocyclization. N-arylation of the β-lactam ring system and a series of functional group transformations synthesized SCH 47949 in a reasonable chemical yield.
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