Portal de Periódicos da CAPES

The Lutheran Blood Groups: A Progress Report with Observations on the Development of the Antigens and Characteristics of the Antibodies

1967; Wiley; Volume: 7; Issue: 3 Linguagem: Inglês

10.1111/j.1537-2995.1967.tb05509.x

1537-2995

Tibor J. Greenwalt, T. Sasaki, E. A. Steane,

Blood disorders and treatments

Scoring titrations with anti‐Lu a on 81 members of the families of seven Lu(a+b—) propositi did not produce any evidence for the presence of Lu genes. In the Lu(a+b+) heterozygotes the Lu a antigen was only weakly expressed at birth increasing progressively during the first 15 years. The red cells of Lu(a+b—) children gave scores comparable to those of adults. The reactions of Lu(a—b+) cord cells were somewhat weaker than those of adults but the red cells of Lu(a+b+) infants reacted very weakly with anti‐Lu a . Four infants born to mothers with anti‐Lu b had no evidence of hemolytic disease due to this antibody. Serologic, immunochemical and ultrafiltration studies suggest that the examples of anti‐Lu b studied are mainly IgA. These observations can explain why no unequivocal examples of hemolytic disease of the newborn due to anti‐Lu b have been encountered.