Produção Nacional
Revisado por pares
The influence of valproic acid on salivary pH in children with cerebral palsy
2007; Wiley; Volume: 27; Issue: 2 Linguagem: Inglês
10.1111/j.1754-4505.2007.tb00330.x
ISSN1754-4505
AutoresWalter L. Siqueira, Maria Teresa Botti Rodrigues Santos, Satheesh Elangovan, Alyne Simões, José Carlos Nicolau,
Tópico(s)Cerebral Palsy and Movement Disorders
ResumoThe purpose of this open-label, crossover study was to measure salivary pH after the oral administration of distilled water, a 10% sucrose solution, and valproic acid to a population of 10 children with cerebral palsy. Salivary pH was measured just prior to giving the solutions and then every five minutes for 60 minutes. The critical pH was defined at 5.5, below which dental demineralization occurs. In this population, valproic acid decreased salivary pH to below the critical pH for an extended period of time (mean = 4.32 at 20 minutes) when compared to mean salivary pH after administration of distilled water (7.11 at 20 minutes) and a 10% sucrose solution (5.96 at 20 minutes). Recovery from this low pH to above the critical level did not occur until after 50 minutes and furthermore did not recover to baseline, neutral levels, for the duration of this study (60 minutes). Our results suggest that children with cerebral palsy, a population with a tendency toward reduced salivary function, have a compromised ability to buffer the oral administration of an exogenous acid. This can result in an increased susceptibility to demineralization and caries of the teeth.
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