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Two Sesquiterpene-Coumarins from the Roots of Ferula marmarica

2004; Elsevier BV; Volume: 63; Issue: 9 Linguagem: Inglês

10.3987/com-04-10157

1881-0942

Yang‐Chang Wu, Mohamed H. Abd El‐Razek, Fang‐Rong Chang, Chih‐Chuang Liaw, Mahmoud I. Nassar, Hui‐Chi Huang, Yung‐Husan Chen, Yuliang Yang,

Synthesis and Biological Activity

Two new sesquiterpene-coumarin conjugates designated foetidin acetate and foetidone were isolated from the roots of Ferula marmarica.The structures of the sesquiterpene-coumarins have been fully characterized by spectroscopic methods, among which foetidin acetate was confirmed by singlecrystal X-Ray crystallography.Absolute configuration of both new compounds was established by CD.Plants of the genus Ferula (family Apiaceae) are long-lived plants, which are widespread throughout the Mediterranean to Central Asia.The gum resins, which are obtained by incision of the roots of several species, are used as spices and drugs in many countries and the resins have been reported to be stomachic, vermifuge and carminative disorders. 1Recently, it has been reported that the sesquiterpene-coumarins from Ferula fukanensis have nitric oxide production inhibitory effects. 2 The genus Ferula is well documented as a good source of secondary metabolites including biologically active compounds such as