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Acute HIV Syndrome after Discontinuation of Antiretroviral Therapy in a Patient Treated before Seroconversion

1998; American College of Physicians; Volume: 128; Issue: 10 Linguagem: Inglês

10.7326/0003-4819-128-10-199805150-00005

1539-3704

Eric S. Daar,

HIV/AIDS drug development and treatment

Brief Communications15 May 1998Acute HIV Syndrome after Discontinuation of Antiretroviral Therapy in a Patient Treated before SeroconversionEric S. Daar, MD, Jiexin Bai, MD, Mary Ann Hausner, MS, Martin Majchrowicz, MPH, Mojgan Tamaddon, BA, and Janis V. Giorgi, PhDEric S. Daar, MDFrom Cedars-Sinai Burns and Allen Research Institute and the University of California, Los Angeles, Los Angeles, California., Jiexin Bai, MDFrom Cedars-Sinai Burns and Allen Research Institute and the University of California, Los Angeles, Los Angeles, California., Mary Ann Hausner, MSFrom Cedars-Sinai Burns and Allen Research Institute and the University of California, Los Angeles, Los Angeles, California., Martin Majchrowicz, MPHFrom Cedars-Sinai Burns and Allen Research Institute and the University of California, Los Angeles, Los Angeles, California., Mojgan Tamaddon, BAFrom Cedars-Sinai Burns and Allen Research Institute and the University of California, Los Angeles, Los Angeles, California., and Janis V. Giorgi, PhDFrom Cedars-Sinai Burns and Allen Research Institute and the University of California, Los Angeles, Los Angeles, California.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-10-199805150-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Primary HIV infection is associated with high levels of viral replication and the development of HIV-specific immune responses [1-5]. Treating patients during primary HIV infection is recommended [6], but little is known about the effects of such therapy [7-9]. We report the results of virologic and immunologic studies in a patient who began receiving antiretroviral therapy during primary HIV infection and chose to discontinue therapy after 6 months.Case ReportA 38-year-old homosexual man presented on day 5 of an acute retroviral syndrome characterized by fever, pharyngitis, myalgia, headache, lymphadenopathy, and rash. The patient's leukocyte count was 2.6 × 109/L, ...References1. Daar ES, Moudgil T, Meyer RD, Ho DD. Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med. 1991; 324:961-4. Google Scholar2. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol. 1994; 68:4650-5. Google Scholar3. Piatak M Jr, Yang LC, Luk KC, Lifson JD, Saag MS, Clark SJ, et al. Viral dynamics in primary HIV-1 infection [Letter]. Lancet. 1993; 341:1099. Google Scholar4. Schacker T, Collier AC, Hughes J, Shea T, Corey L. Clinical and epidemiologic features of primary HIV infection. Ann Intern Med. 1996; 125:257-64. Google Scholar5. Musey L, Hughes J, Schacker T, Shea T, Corey L, McElrath MJ. 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Google Scholar Author, Article, and Disclosure InformationAffiliations: From Cedars-Sinai Burns and Allen Research Institute and the University of California, Los Angeles, Los Angeles, California.Acknowledgments: The authors thank Stephen Nichols, MD, for technical assistance; Jacqui Pitt, RN, for clinical assistance; Marie Reskusic for figure preparation; and John Ferbas, PhD, for critical review of the manuscript. They also thank the patient, who cooperated with all studies and reviewed the manuscript to assure accuracy of the description of the clinical syndrome.Grant Support: In part by the Universitywide AIDS Research Program California Multicenter AIDS Research Consortium Award and National Institutes of Health grant AI-32883.Corresponding Author: Eric S. Daar, MD, Division of Infectious Diseases, Cedars-Sinai Medical Center, B217, 8700 Beverly Boulevard, Los Angeles, CA 90048.Current Author Addresses: Drs. Daar and Bai and Ms. Tamaddon: Division of Infectious Diseases, Cedars-Sinai Medical Center, B217, 8700 Beverly Boulevard, Los Angeles, CA 90048. 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Pat Bucy, MD, PhDPrimary HIV infectionAntiretroviral Therapy during Primary Immunodeficiency Virus Infection Can Induce Persistent Suppression of Virus Load and Protection from Heterologous Challenge in Rhesus MacaquesHuman anti-HIV-1 tat sFv intrabodies for gene therapy of advanced HIV-1-infection and AIDSThe challenge of immune control of immunodeficiency virusDynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapyFailure to Learn Human Immunodeficiency Virus Test Results in Los Angeles Public Sexually Transmitted Disease Clinics 15 May 1998Volume 128, Issue 10Page: 827-829KeywordsAntibodiesAntiretroviral therapyBlood plasmaCellsCytotoxic T cellsHIVHIV infectionsImmune responseMemoryRNA Issue Published: 15 May 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...