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Comparison of 1.0 M Gadobutrol and 0.5 M Gadopentetate Dimeglumine-Enhanced Magnetic Resonance Imaging in Five Hundred Seventy-Two Patients With Known or Suspected Liver Lesions

2009; Lippincott Williams & Wilkins; Volume: 44; Issue: 3 Linguagem: Inglês

10.1097/rli.0b013e318198a0ae

1536-0210

Renate Hammerstingl, Gerhard Adam, Juan-Ramón Ayuso, Bernard E. Van Beers, Giuseppe Belfiore, Marie‐France Bellin, G. Bongartz, Olivier Ernst, Bernd Frericks, Gianmarco Giuseppetti, Gertrud Heinz-Peer, Andrea Laghi, Julio Martín, Christiane Pering, Peter Reimer, Götz-Martin Richter, Frank W. Roemer, F. Schäfer, Valérie Vilgrain, Thomas J. Vogl, Dominik Weishaupt, Alexander Wall, Christoph J. Zech, Bernd Tombach,

Advanced MRI Techniques and Applications

Objective: To evaluate the diagnostic efficacy (accuracy, sensitivity, specificity) of 1.0 M gadobutrol versus 0.5 M gadopentetate for the classification of lesions as either benign or malignant in patients with known or suspected liver lesions. Methods and Materials: A multicenter, phase-III, randomized, interindividually controlled comparison study with blinded reader evaluation was performed to investigate the diagnostic efficacy of a bolus injection of 1.0 M gadobutrol compared with 0.5 M gadopentetate at a dose of 0.1 mmol Gd/kg BW. The imaging protocol included a dynamic 3D-evaluation, static conventional, and fat saturated T1-weighted sequences. MR datasets were evaluated by 3 independent radiologists. The standard of reference was defined by an independent truth panel (radiologist or hepatologist). The safety evaluation included adverse events, vital signs, and physical examination. Results: A total of 497 of 572 patients were eligible for the final efficacy analysis. Noninferiority of gadobutrol-enhanced magnetic resonance imaging (MRI) for the classification of liver lesions was demonstrated on the basis of diagnostic accuracy determined by the on-site investigators (−0.098, 0.021) as well as for the average reader of the blinded evaluation (−0.096, 0.014) (95% confidence interval), compared with the predefined standard of reference. Very similar increases in sensitivity (ranging from ∼10% to ∼55%) and specificity (ranging from ∼1%–∼18%) compared with precontrast MRI were also observed for the 2 contrast agent groups, with maximum differences of 4%. Very similar, low rates of adverse events were recorded for each of the 2 groups. No clinically relevant changes in vital signs or the results of the physical examination were observed in any patient. Conclusion: This study documents evidence for the noninferiority of a single i.v. bolus injection of 1.0 M gadobutrol (0.1 mmol/kg body weight) to 0.5 M gadopentetate (0.1 mmol/kg body weight) in the diagnostic assessment of liver lesions with contrast-enhanced MRI. The known excellent safety profile of gadobutrol was confirmed in this clinical trial and is similar to that of gadopentetate.