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Synthesis, Structure of Nitrogen-Containing Phosphinogold(I) Ferrocenes. In vitro Activity against Bladder and Colon Carcinoma Cell Lines

1995; Hindawi Publishing Corporation; Volume: 2; Issue: 6 Linguagem: Inglês

10.1155/mbd.1995.311

0793-0291

Manuella Viotte, B. Gautheron, Marek M. Kubicki, Ilya E. Nifant’ev, Simon P. Fricker,

Organophosphorus compounds synthesis

The gold salt [(tht)AuCl] was reacted with [1‐N,N‐dimethylaminométhyl‐2‐diphenylphosphino]ferrocene (1) forming the bimetallic derivative 4. The reaction of methyl iodide and tetramethylammonium bromide on the chloride 4 produced the ammonium salt 5 and the bromide 6 respectively. New aminophosphines 2 and 3, which represent two of the rare phosphorylated metallocenes containing P(III)‐N bond have also been coordinated to gold(I) to form 7 and 8. The presence of the ethoxy group in 7 provides evidence for the lability of one nitrogen‐phosphorus bond. The X‐ray structure of compounds 4 and 7 have been established. Both crystallize in space group P2 1 /c, monoclinic, with a = 11.095(2) Å, b = 12.030(3) Å, c = 17.763(4) Å, β= 94.02(2) ∘ , Z = 4 for 4 and a = 14.863(3) Å, b = 8.036(5)Å, c = 18.062(5)Å, β =101.64(1)°, Z = 4 for 7. 197 Au Mössbauer data are in good agreement with those for other linear P‐Au‐Cl containing complexes. The compounds were evaluated for in vitro anti‐tumour activity against two human tumours. Differential cytotoxicity was observed with activity comparable to cisplatin, with the exception of one compound which was significantly more cytotoxic.