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Otx genes in neurogenesis of mesencephalic dopaminergic neurons

2011; Wiley; Volume: 71; Issue: 8 Linguagem: Inglês

10.1002/dneu.20877

1932-846X

Antonio Simeone, Eduardo Puelles, Daniela Omodei, Dario Acampora, Luca Giovanni Di Giovannantonio, Michela Di Salvio, Pietro Mancuso, Carmine Tomasetti,

Pluripotent Stem Cells Research

Abstract Mesencephalic‐diencephalic dopaminergic (mdDA) neurons play a relevant role in the control of movement, behavior, and cognition. Indeed loss and/or abnormal functioning of mdDA neurons are responsible for Parkinson's disease as well as for addictive and psychiatric disorders. In the last years a wealth of information has been provided on gene functions controlling identity, fate, and proliferation of mdDA progenitors. This review will focus on the role exerted by Otx genes in early decisions regulating sequential steps required for the neurogenesis of mesencephalic dopaminergic (mesDA) neurons. In this context, the regulatory network involving Otx functional interactions with signaling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in detail. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 71:665–679, 2011