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Immunologic and Testicular Response in Guinea Pigs after Unilateral Traumatic Orchitis

2009; Wiley; Volume: 8; Issue: 3 Linguagem: Inglês

10.1111/j.1439-0272.1976.tb02141.x

1439-0272

Leonardo Fainboim, Clydes Barrera, Roberto E. Mancini,

Coccidia and coccidiosis research

AndrologiaVolume 8, Issue 3 p. 243-248 Immunologic and Testicular Response in Guinea Pigs after Unilateral Traumatic Orchitis L. FAINBOIM, Corresponding Author L. FAINBOIM Centro de Investigaciones en Reproductión, Facultad de Medicina, Paraguay 2155, Piso 10, Buenos Aires, ArgentinaCentro de Investigaciones en Reproductión, Facultad de Medicina, Paraguay 2155, Piso 10, Buenos Aires, ArgentinaSearch for more papers by this authorClydes N. BARRERA, Clydes N. BARRERA Centro de Investigaciones en Reproductión, Facultad de Medicina, Paraguay 2155, Piso 10, Buenos Aires, ArgentinaSearch for more papers by this authorR.E. MANCINI, R.E. MANCINI Centro de Investigaciones en Reproductión, Facultad de Medicina, Paraguay 2155, Piso 10, Buenos Aires, ArgentinaSearch for more papers by this author L. FAINBOIM, Corresponding Author L. FAINBOIM Centro de Investigaciones en Reproductión, Facultad de Medicina, Paraguay 2155, Piso 10, Buenos Aires, ArgentinaCentro de Investigaciones en Reproductión, Facultad de Medicina, Paraguay 2155, Piso 10, Buenos Aires, ArgentinaSearch for more papers by this authorClydes N. BARRERA, Clydes N. BARRERA Centro de Investigaciones en Reproductión, Facultad de Medicina, Paraguay 2155, Piso 10, Buenos Aires, ArgentinaSearch for more papers by this authorR.E. MANCINI, R.E. MANCINI Centro de Investigaciones en Reproductión, Facultad de Medicina, Paraguay 2155, Piso 10, Buenos Aires, ArgentinaSearch for more papers by this author First published: July‐September 1976 https://doi.org/10.1111/j.1439-0272.1976.tb02141.xCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Summary An acute and intense trauma was inflicted in one of the testes of adult guinea pigs. The immunological response and histological changes developed both in the injured and contralateral glands were studied at different intervals of time. It was observed: 1) Necrotic seminiferous tubules and a granulomatous cell reaction were seen in the injured gonad at 15 days. This was followed by a reduction of the mononuclear cell infiltration at 48 days. Finally a fibrotic tissue replaced the damaged areas at around 100 days. 2) Foci showing the classical picture of immunologic orchitis appeared in the contralateral gland at 15 and 48 days. Less frequent lesions were detected in the final period of the experiment. 3) These lesions were accompanied by cellular immunity detectable by the macrophage migration inhibition test at 15 and 48 days. With the exception of cytophilic activity also detected in same periods, no antibodies of hemagglutinating and sperm-agglutinating types could be found. Zusammenfassung Bei Meerschweinchen wurde ein schweres, akutes Trauma auf einen Hoden ausge-übt und anschließend die immunologische und histologische Reaktion sowohl an dem traumatisierten als auch an dem kontralateralen Hoden beobachtet. Folgende Resultate werden festgestellt: a) Nach 15 Tagen kommt es bei der traumatisierten Gonade zu einer Nekrose der Tubuli seminiferi und zu einer granulomatösen Reaktion. Nach 48 Tagen folgte eine Reduzierung der mononukleären Zellreaktion. Nach 100 Tagen zeigte sich in den traumatisierten Bezirken Bindegewebe. b) Auf der kontralateralen Seite wurde nach 15–48 Tagen das Auftreten von Herden mit dem klassischen Bild der immunologischen Orchitis beobachtet. c) Diese Veränderungen ließen sich zur gleichen Zeit mit dem Makrophasen-Migrations-Test nachweisen. Mit Ausnahme der cytophilen Aktivität, die zur gleichen Zeit bestimmt wurde, wurden keine Antikörper der Haemag-glutinations- und der Spermagglutinations-Typen gefunden. References Barrera, C.N. and A.B. Mazzolli: Cytophilic activity in experimental immunologic orchitis in guinea pigs. Fertil. Steril. 27, 21 (1976). 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Katsh: Induction of aspermatogenesis by passive transfer of immune sera or cells. Int. Arch. Allergy 46, 172 (1972). Zappi, E. and S. Shulman: Early histological changes in experimental contralateral epididymoorchitis in the rabbit. J. Reprod. Fert. 36, 23 (1974). Citing Literature Volume8, Issue3July‐September 1976Pages 243-248 ReferencesRelatedInformation