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Hematological alterations during experimental canine infection by Trypanosoma cruzi

2012; Colégio Brasileiro de Parasitologia Veterinaria; Volume: 21; Issue: 2 Linguagem: Inglês

10.1590/s1984-29612012000200015

1984-2961

Paulo Marcos da Matta Guedes, Vanja Maria Veloso, Tiago Wilson Patriarca Mineo, Juliana Santiago-Silva, Geovan Crepalde, Ivo Santana Caldas, Manuela Sales Lima Nascimento, Marta de Lana, Égler Chiari, Lúcia Maria da Cunha Galvão, Maria Terezinha Bahia,

Parasitic Infections and Diagnostics

To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosomacruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Simultaneously, we observed anemia, leukocytosis and lymphocytosis. Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T.cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease.