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BIBTEX RIS

Lenalidomide induces degradation of IKZF1 and IKZF3

2014; Landes Bioscience; Volume: 3; Issue: 7 Linguagem: Inglês

10.4161/21624011.2014.941742

ISSN

2162-402X

Autores

Jan Krönke, Slater N. Hurst, Benjamin L. Ebert,

Tópico(s)

Ubiquitin and proteasome pathways

Resumo

Lenalidomide and its analogs, thalidomide and pomalidomide, specifically inhibit growth of mature B-cell lymphomas, including multiple myeloma, and induce interleukin-2 (IL-2) release from T cells. We recently found that this results from activation of the CRBN-CRL4 E3 ubiquitin ligase to degrade the lymphoid transcription factors IKZF1 (Ikaros) and IKZF3 (Aiolos).

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