Portal de Periódicos da CAPES

What Is Primary and What Secondary for Amyloid Deposition in Alzheimer's Disease

1994; Wiley; Volume: 719; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1994.tb56831.x

1749-6632

W. Meier‐Ruge, P. Iwangoff, Carlo Bertoni–Freddari,

Dementia and Cognitive Impairment Research

Annals of the New York Academy of SciencesVolume 719, Issue 1 p. 230-237 What Is Primary and What Secondary for Amyloid Deposition in Alzheimer's Disease W. MEIER-RUGE, W. MEIER-RUGE Division of Gerontological Brain Research Department of Pathology University Medical School Basel Schönbeinstrasse 40 CH-4003 Basel, SwitzerlandSearch for more papers by this authorP. IWANGOFF, P. IWANGOFF Division of Gerontological Brain Research Department of Pathology University Medical School Basel Schönbeinstrasse 40 CH-4003 Basel, SwitzerlandSearch for more papers by this authorC. BERTONI-FREDDARI, C. BERTONI-FREDDARI Italian National Research Center on Aging (INRCA) Gerontological Research Department Via Birarelli 8 1-60121 Ancona, ItalySearch for more papers by this author W. MEIER-RUGE, W. MEIER-RUGE Division of Gerontological Brain Research Department of Pathology University Medical School Basel Schönbeinstrasse 40 CH-4003 Basel, SwitzerlandSearch for more papers by this authorP. IWANGOFF, P. IWANGOFF Division of Gerontological Brain Research Department of Pathology University Medical School Basel Schönbeinstrasse 40 CH-4003 Basel, SwitzerlandSearch for more papers by this authorC. BERTONI-FREDDARI, C. BERTONI-FREDDARI Italian National Research Center on Aging (INRCA) Gerontological Research Department Via Birarelli 8 1-60121 Ancona, ItalySearch for more papers by this author First published: May 1994 https://doi.org/10.1111/j.1749-6632.1994.tb56831.xCitations: 23AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 St. George-Hyslop, P. St. 1990. Genetic linkage studies suggest that Alzheimer's disease is not a single homogenous disorder. Nature 347: 194–197. 10.1038/347194a0 CASPubMedWeb of Science®Google Scholar 2 Sinex, M. E. & C. R. Merrill, Eds. 1982. Alzheimer's Disease, Down Syndrome and Aging. Ann. N.Y. Acad. Sci. 396. Google Scholar 3 Beyreuther, K., A. I. Bush, Th. Dyrks, C. Hilbich, G. Konig, U. Monning, G. Multhaup, R. Prior, B. Rumble, W. Schubert, D. H. Small, A. Weidemann & C. L. Masters. 1991. Mechanisms of amyloid deposition in Alzheimer's disease. Ann. N.Y. Acad. Sci. 640: 129–139. 10.1111/j.1749-6632.1991.tb00204.x CASPubMedWeb of Science®Google Scholar 4 Estus, ST., T. E. Golde & ST. G. Younkin. 1992. Normal processing of the Alzheimer's disease amyloid-beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives. Ann. N.Y. Acad. Sci. 674: 138–148. 10.1111/j.1749-6632.1992.tb27483.x CASPubMedWeb of Science®Google Scholar 5 Kosik, K. S. 1992. Alzheimer's disease: a cell biological perspective. Science 256: 780–783. 10.1126/science.1589757 CASPubMedWeb of Science®Google Scholar 6 Sinha, S. & I. Lieberburg. 1992. Normal metabolism of the amyloid precursor protein (APP). Neurodegeneration 1: 169–175. Google Scholar 7 Goate, A., M.-C. Chartier-Harlin, M. Mullan, J. Brown, F. Crawford, L. Fidani, L. Giuffra, A. Haynes, N. Irvin, L. James, R. Mant, P. Newton, K. Rooke, P. Roques, C. Talbot, M. Pericak-Vance, A. Roses, R. Williamson, M. Rossor, M. Owen & J. Hardy. 1991. Segregation of a missense mutation in the amyloid precursor protein gene, with familial Alzheimer's disease. Nature 399: 704–706. 10.1038/349704a0 PubMedWeb of Science®Google Scholar 8 Chartier-Harlin, M.-C, F. Crawford, H. Houlden, A. Warren, D. Hughes, L. Fidani, A. Goate, M. Rossor, P. Roques, J. Hardy & M. Mullan. 1991. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 353: 844–846. 10.1038/353844a0 CASPubMedWeb of Science®Google Scholar 9 Selkoe, D. J. 1991. Amyloid protein and Alzheimer's disease. Sci. Am. 11: 40–47. Google Scholar 10 Robakis, N. K., H. M. Wisniewski, E. C. Jenkins, E. A. Devine-Gage, G. E. Houck, X.-L. Yao, N. Ramakrishna, G. Wolfe, W. P. Silverman & W. T. Brown. 1987. Chromosome 21 q 21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer's disease and Down syndrome. Lancet i: 384–385. 10.1016/S0140-6736(87)91754-5 CASGoogle Scholar 11 Meier-Ruge, W., O. Hunziker & P. Iwangoff. 1991. Senile dementia: a threshold phenomenon of normal aging? A contribution to the functional reserve hypothesis of the brain. Ann. N.Y. Acad. Sci. 621: 104–118. 10.1111/j.1749-6632.1991.tb16973.x CASPubMedWeb of Science®Google Scholar 12 Iwangoff, P., R. Armbruster, A. Enz, W. Meier-Ruge & P. Sandoz. 1980. Glycolytic enzymes from human autoptic brain cortex: normally aged and demented cases. In Biochemistry of Dementia. P. J. Roberts, Ed. 258–262. Wiley. Chichester . Google Scholar 13 Iwangoff, P., R. Armbruster, A. Enz & W. Meier-Ruge. 1980. Glycolytic enzymes from human autoptic brain cortex: normal aged and demented cases. Mech. Aging Dev. 14: 203–209. 10.1016/0047-6374(80)90120-7 CASPubMedWeb of Science®Google Scholar 14 Meier-Ruge, W. 1985. Neurochemistry of the aging brain and senile dementia. In Aging 2000: Our Health Care Destiny. Ch. Gaitz & T. Samorajski, Eds. 101–112. S. Springer. New York . 10.1007/978-1-4612-5058-6_8 Google Scholar 15 Hoyer, S. 1988. Glucose and related brain metabolism in normal aging. Age 11: 150–156. 10.1007/BF02432295 CASWeb of Science®Google Scholar 16 Roubicek, J. 1977. The electroencephalogram in the middle-aged and the elderly. J. Am. Geriatr. Soc. 25: 145–152. 10.1111/j.1532-5415.1977.tb00282.x CASPubMedWeb of Science®Google Scholar 17 Matejcek, M. 1981. Das EEG am alternden Menschen-einige Befunde und Folgerungen für die Geriatrie-Forschung. In Funktionsstorungen des Gehirns im Alter. D. Piatt, Ed.: 145–159. F. K. Schattaner Verlag. Stuttgart & New York . Google Scholar 18 Meier-Ruge, W. 1990. Senile dementia-a disease of exhaustion of functional brain reserve capacity. Excerpta Med. Curr. Clin. Pract. Ser. 59: 371–375. Google Scholar 19 Gottfries, C. G. 1990. Neurochemical aspects of dementia disorders. Dementia 1: 56–64. 10.1159/000107121 Google Scholar 20 Probst, A., H. Brunnschweiler, C. Lautenschlager & J. Ulrich. 1987. A special type of senile plaque, possibly an initial stage. Acta Neuropathol. (Berlin) 74: 133–141. 10.1007/BF00692843 CASPubMedWeb of Science®Google Scholar 21 Beer, R. E. & J. Ulrich. 1993. Alzheimer plaques density and duration of dementia. Arch. Gerontol. Geriatr. 16: 1–7. 10.1016/0167-4943(93)90021-9 CASPubMedWeb of Science®Google Scholar 22 Ulrich, J. 1993. The neuropathology of senile dementia. In Dementing Brain Disease in Old Age. Teaching and Training in Geriatric Medicine. W. Meier-Ruge, Ed. 3: 1–33. S. Karger. Basel . Google Scholar 23 Selkoe, D. J. 1989. Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease. Neurobiol. Aging 10: 387–395. 10.1016/0197-4580(89)90072-9 CASPubMedWeb of Science®Google Scholar 24 Probst, A., D. Langui, S. Ipsen, N. Robakis & J. Ulrich. 1991. Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques. Acta Neuropathol. (Berlin) 83: 21–29. 10.1007/BF00294426 PubMedWeb of Science®Google Scholar 25 Jellinger, K. 1987. Quantitative changes in some subcortical nuclei in aging, Alzheimer's disease and Parkinson's disease. Neurobiol. Aging 8: 556–561. 10.1016/0197-4580(87)90134-5 CASPubMedWeb of Science®Google Scholar 26 Jellinger, K., H. Lassmann, P. Fischer & W. Danielczyk. 1991. Validation of diagnostic criteria for Alzheimer's disease. In Alzheimer's Disease. Basic Mechanisms, Diagnosis and Therapeutic Strategies. K. Iqbal, D. R. C. McLachlan, B. Winblad & H. M. Wisniewski, Eds. 75–89. John Wiley & Sons. New York . Web of Science®Google Scholar 27 Meier-Ruge, W., P. Iwangoff & K. Reichlmeier. 1984. Neurochemical enzyme changes in Alzheimer's and Pick's disease. Arch. Gerontol. Geriatr. 3: 161–165. 10.1016/0167-4943(84)90007-4 CASPubMedWeb of Science®Google Scholar 28 Bowen, D. M., J. A. Spillane, G. Curzon, W. Meier-Ruge, P. White, M. J. Goodhardt, P. Iwangoff & A. N. Davison. 1979. Accelerated aging or selective neuronal loss as an important cause of dementia Lancet i: 11–14. Google Scholar 29 Hoyer, S. 1988. Glucose and related brain metabolism in dementia of Alzheimer type and its morphological significance. Age 11: 158–166. 10.1007/BF02432296 Web of Science®Google Scholar 30 Hoyer, S. 1991. Abnormalities of glucose metabolism in Alzheimer's disease. Ann. N.Y. Acad. Sci. 640: 53–58. 10.1111/j.1749-6632.1991.tb00190.x CASPubMedWeb of Science®Google Scholar 31 Wallace, D. C. 1992. Mitochondrial genetics: a paradigm for aging and degenerative disease Science 256: 628–632. 10.1126/science.1533953 CASPubMedWeb of Science®Google Scholar 32 Hoyer, S. 1991. Brain energy metabolism and its significance for Alzheimer's disease. In Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies. K. Iqbal, D. R. C. McLachlan, B. Winblad & H. M. Wisniewski, Eds. 53–57. John Wiley & Sons. New York . Web of Science®Google Scholar 33 Heiss, W.-D., B. Szelies, J. Kessler & K. Herholz. 1991. Abnormalities of energy metabolism in Alzheimer's disease studied with PET. Ann. N.Y. Acad. Sci. 640: 65–71. 10.1111/j.1749-6632.1991.tb00192.x CASPubMedWeb of Science®Google Scholar 34 Meier-Ruge, W., J. Ulrich & H. B. Stahelin. 1985. Morphometric investigation of nerve cells, neuropil and senile plaques in senile dementia of the Alzheimer type. Arch. Gerontol. Geriatr. 4: 219–229. 10.1016/0167-4943(85)90004-4 CASPubMedWeb of Science®Google Scholar 35 Bertoni-Freddari, C., P. Fattoretti, T. Casoli, W. Meier-Ruge & J. Ulrich. 1990. Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease. Brain Res. 517: 69–75. 10.1016/0006-8993(90)91009-6 CASPubMedWeb of Science®Google Scholar 36 Bertoni-Freddari, C., P. Fattoretti, T. Casoli, W. Meier-Ruge & J. Ulrich. 1991. Reactive capacities of the central nervous system in physiological aging and senile dementia of the Alzheimer type. Ann. N.Y. Acad. Sci. 621: 98–103. 10.1111/j.1749-6632.1991.tb16972.x CASPubMedWeb of Science®Google Scholar 37 Bertoni-Freddari, C, P. Fattoretti, M. Pieroni, W. Meier-Ruge & J. Ulrich. 1992. Enlargement of synaptic size as a compensative reaction in aging and dementia. Pathol. Res. Pract. 188: 612–615. 10.1016/S0344-0338(11)80066-X CASPubMedWeb of Science®Google Scholar 38 Landin, K., K. Blennow, A. Wallin & C.-G. Gottfries. 1993. Low blood pressure and blood glucose levels in Alzheimer's disease. Evidence for a hypometabolic disorder J. Intern. Med. 233: 357–363. 10.1111/j.1365-2796.1993.tb00684.x CASPubMedWeb of Science®Google Scholar 39 Tucek, S. 1985. Regulation of acetylcholine synthesis in the brain. J. Neurochem. 44: 11–24. 10.1111/j.1471-4159.1985.tb07106.x CASPubMedWeb of Science®Google Scholar 40 Tucek, S. 1988. Choline acetyltransferase and the synthesis of acetylcholine. In Hand-book of Experimental Pharmacology. V. P. Whittaker, Ed. Vol. 86: 125–165. Springer. Heidelberg . Google Scholar 41 Tucek, S., J. Ricny & V. Dolezal. 1990. Advances in the biology of cholinergic neurons. Adv. Neurol. 51: 109–115. CASPubMedGoogle Scholar 42 Perry, E. K. 1980. The cholinergic system in old age and Alzheimer's disease. Age Ageing 9: 1–8. 10.1093/ageing/9.1.1 CASPubMedWeb of Science®Google Scholar 43 Perry, E. K., B. E. Tomlinson, G. Blessed, K. Bergmann, P. H. Gibson & R. H. Perry. 1978. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br. Med. J. 2: 1457–1459. 10.1136/bmj.2.6150.1457 CASPubMedWeb of Science®Google Scholar 44 Perry, E. K. 1986. The cholinergic hypothesis-ten years on. Br. Med. Bull. 42: 63–69. 10.1093/oxfordjournals.bmb.a072100 CASPubMedWeb of Science®Google Scholar 45 Benson, D. F., D. E. Kuhl, R. A. Hawkins, M. E. Phelps, J. L. Cummings & S. Y. Tsai. 1983. The fluorodeoxyglucose 18F scan in Alzheimer's disease and multiinfarct dementia. Arch. Neurol. 40: 711–714. 10.1001/archneur.1983.04050110029003 CASPubMedWeb of Science®Google Scholar 46 Duara, R., C. Grady, J. Haxby, M. Sundaram, N. R. Cutler, L. Heston, A. Moore, N. Schlageter, S. Larson & S. I. Rapoport. 1986. Positron emission tomography in Alzheimer's disease. Neurology 36: 879–887. 10.1212/WNL.36.7.879 CASPubMedWeb of Science®Google Scholar 47 Haxby, J. V., C. L. Grady, R. Duara, N. Schlageter, G. Berg & S. I. Rapoport. 1986. Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's type dementia. Arch. Neurol. 43: 882–885. 10.1001/archneur.1986.00520090022010 PubMedWeb of Science®Google Scholar 48 Matsuzawa, T., H. Matsui, K. Mecuro, M. Ueda, K. Yamada, T. Yamaguchi, M. Itoh, J. Hatazawa & S. Kinomura. 1990. Characteristics of cerebral glucose utilization in dementia. Sci. Rep. Res. Inst. Tohoku Univ. 37: 11–21. CASPubMedGoogle Scholar 49 Parker, W. D., Ch. M. Filley & J. Kparks. 1990. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40: 1302–1303. 10.1212/WNL.40.8.1302 PubMedWeb of Science®Google Scholar 50 Stephenson, D. T., M. B. Podlinsny, D. Games, I. Lieberburg, D. J. Selkoe & J. A. Clemens, 1992. Effects of implants of beta-amyloid protein in monkey cerebral cortex. Neurodegeneration 1: 177–187. Google Scholar 51 Selkoe, D. J., M. D. Podlinsny, C Joachim. E. A. Vickers, G. Lee, L. C. Fritz & T. Oltersdorf. 1988. Beta-amyloid precursor protein of Alzheimer's disease occurs at 110- to 135-kilodalton membrane-associated proteins in neural and nonneu-ral tissues. Proc. Natl. Acad. Sci. USA 85: 7341–7345. 10.1073/pnas.85.19.7341 CASPubMedWeb of Science®Google Scholar 52 Lajtha, A., M. Banay-Schwartz & D. Dunlop. 1992. Protein metabolism in the brain. Ann. N.Y. Acad. Sci. 674: 16–26. 10.1111/j.1749-6632.1992.tb27473.x CASPubMedWeb of Science®Google Scholar 53 Mönning, U., G. Konig, R. Prior, H. Mechler, U. Schreiter-Gasser, C. L. Masters & K. Beyreuther. 1991. Synthesis and secretion of Alzheimer amyloid beta A4 precursor protein by stimulated human peripheral blood lymphocytes. FEBS Lett. 277: 261–266. 10.1016/0014-5793(90)80861-C PubMedWeb of Science®Google Scholar 54 Roberts, G. W., S. M. Gentleman, A. Lynch & D. I. Graham. 1991. Beta-A4 amyloid protein deposition in brain after head trauma. Lancet 338: 1422–1423. 10.1016/0140-6736(91)92724-G CASPubMedWeb of Science®Google Scholar 55 Regland, B. & C.-G. Gottfries. 1992. The role of amyloid beta-protein in Alzheimer's disease. Lancet 340: 467–469. 10.1016/0140-6736(92)91780-C CASPubMedWeb of Science®Google Scholar 56 Estus, S., T. E. Golde, T. Kunishita, D. Blades, D. Lowery, M. Eisen, M. Usiak, X. M. Qu, T. Tabira, B. D. Greenberg & S. G. Younkin. 1992. Potentially amyloidogenic carboxyl-terminal derivatives of the amyloid protein precursor. Science 255: 726–728. 10.1126/science.1738846 CASPubMedWeb of Science®Google Scholar 57 Potter, H., R. B. Nelson, S. Das, R. Siman, U. S. Kayyali & D. Dressler. 1992. The involvement of proteases, protease inhibitors and an acute phase response in Alzheimer's disease. Ann. N.Y. Acad. Sci. 674: 161–173. 10.1111/j.1749-6632.1992.tb27485.x CASPubMedWeb of Science®Google Scholar 58 Gandy, S. E., G. L. Caporaso, T. V. Ramabhadran, T. Suzuki, J. D. Buxbaum, Ch. Nordstedt, K. Iverfeldt, A. J. Czernik, A. C. Nairn & P. Greengard. 1992. Characterization of alternative routes for processing of the Alzheimer beta/ A4-amyloid precursor protein. Ann. N.Y. Acad. Sci. 674: 203–217. 10.1111/j.1749-6632.1992.tb27489.x CASPubMedWeb of Science®Google Scholar 59 Saitoh, T., E. Masliah, L. Baum, M. Sundsmo, L. Flanagan, R. Vikramkumar & M. M. B. Kay. 1992. Degradation of proteins in the membrane-cytoskeleton complex in Alzheimer's disease. Ann. N.Y. Acad. Sci. 674: 180–192. 10.1111/j.1749-6632.1992.tb27487.x CASPubMedWeb of Science®Google Scholar 60 Koo, E. H., S. S. Sisodia, D. R. Archer, L. J. Martn, A. Wiedemann, K. Beyreuther, P. Fischer, C. L. Masters & D. L. Price. 1990. Precursor of amyloid protein in Alzheimer's disease undergoes fast anterograde axonal transport. Proc. Natl. Acad. Sci. USA 87: 1561–1565. CASPubMedGoogle Scholar 61 Gandy, S., A. J. Czernik & P. Greengard. 1988. Phosphorylation of Alzheimer's disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-depen-dent protein kinase II. Proc. Natl. Acad. Sci. USA 85: 6218–6221. 10.1073/pnas.85.16.6218 CASPubMedWeb of Science®Google Scholar 62 Caporaso, G. L., S. E. Gandy, J. D. Buxbaum, T. V. Ramabhadran & P. Greengard. 1992. Protein phosphorylation regulates secretion of Alzheimer's beta/A4 amyloid precursor protein. Proc. Natl. Acad. Sci. USA 89: 3055–3059. 10.1073/pnas.89.7.3055 CASPubMedWeb of Science®Google Scholar 63 Shoji, M. T., E. Golde, J. Ghiso, T. Tcheung, ST. Estus, M. Schaffer, X.-D. Cai, D. M. McKay, R. Tintner, B. Frangione & St. G. Younkin. 1992. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science 258: 126–129. 10.1126/science.1439760 CASPubMedWeb of Science®Google Scholar 64 Haass, C, E. H. Koo, A. Mellon, A. Y. Hung & D. J. Selkoe. 1992. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357: 500–503. 10.1038/357500a0 CASPubMedWeb of Science®Google Scholar 65 Erecinska, M. & I. A. Silver. 1989. ATP and brain function. J. Cereb. Blood Flow Metab. 9: 2–19. 10.1038/jcbfm.1989.2 CASPubMedWeb of Science®Google Scholar 66 Dice, J. F. 1992. Selective degradation of cytosolic proteins by lysosomes. Ann. N.Y. Acad. Sci. 674: 58–64. 10.1111/j.1749-6632.1992.tb27477.x CASPubMedWeb of Science®Google Scholar 67 Liguri, G., N. Taddei, P. Nassi, S. Latorraca, C. Nediani & S. Sorbi. 1990. Changes in Na, K-ATPase, Ca2+-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease. Neurosci. Lett. 112: 338–342. 10.1016/0304-3940(90)90227-Z CASPubMedWeb of Science®Google Scholar 68 Buratowski, ST. 1993. DNA repair and transcription: the helicase connection. Science 260: 37–38. 10.1126/science.8465198 CASPubMedWeb of Science®Google Scholar Citing Literature Volume719, Issue1The Aging Clock: The Pineal Gland and Other Pacemakers in the Progression of Aging and CarcinogenesisMay 1994Pages 230-237 ReferencesRelatedInformation