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Haplotype Analysis of Prostate Stem Cell Antigen and Association With Prostate Cancer Risk

2011; Lippincott Williams & Wilkins; Volume: 185; Issue: 6 Linguagem: Inglês

10.1016/j.juro.2011.01.083

1527-3792

Jae Young Joung, Yeon-Su Lee, Sohee Park, Hye-Kyoung Yoon, Sang Jin Lee, Weon Seo Park, Ho Kyung Seo, Jinsoo Chung, Soo-kyoung Kim, Seung-Hyun Hong, Jeong Seon Kim, Kang Hyun Lee,

Cancer-related molecular mechanisms research

No AccessJournal of UrologyAdult Urology1 Jun 2011Haplotype Analysis of Prostate Stem Cell Antigen and Association With Prostate Cancer Risk Jae Young Joung, Yeon-Su Lee, Sohee Park, Hyekyoung Yoon, Sang Jin Lee, Weon Seo Park, Ho Kyung Seo, Jinsoo Chung, Sook-young Kim, Seung-Hyun Hong, Jeong Seon Kim, and Kang Hyun Lee Jae Young JoungJae Young Joung Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea , Yeon-Su LeeYeon-Su Lee Functional Genomics Branch, National Cancer Center, Goyang, Republic of Korea , Sohee ParkSohee Park Cancer Biostatistics Branch, National Cancer Center, Goyang, Republic of Korea , Hyekyoung YoonHyekyoung Yoon Cancer Biostatistics Branch, National Cancer Center, Goyang, Republic of Korea , Sang Jin LeeSang Jin Lee Genitourinary Cancer Branch, National Cancer Center, Goyang, Republic of Korea , Weon Seo ParkWeon Seo Park Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea , Ho Kyung SeoHo Kyung Seo Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea , Jinsoo ChungJinsoo Chung Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea , Sook-young KimSook-young Kim Functional Genomics Branch, National Cancer Center, Goyang, Republic of Korea , Seung-Hyun HongSeung-Hyun Hong Functional Genomics Branch, National Cancer Center, Goyang, Republic of Korea , Jeong Seon KimJeong Seon Kim Cancer Epidemiology Branch, National Cancer Center, Goyang, Republic of Korea , and Kang Hyun LeeKang Hyun Lee Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea View All Author Informationhttps://doi.org/10.1016/j.juro.2011.01.083AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Prostate stem cell antigen has become a promising target as a potential biomarker for prostate cancer, but to our knowledge there are no reports of a genetic variation of the PSCA gene associated with prostate cancer risk. We determined the potential association between specific variations of the PSCA gene and prostate cancer in Korean men. Materials and Methods: In this hospital based, case-control study 194 patients newly diagnosed with histologically confirmed prostate cancer were enrolled. Visitors for cancer screening served as healthy controls. We genotyped 12 PSCA gene single nucleotide polymorphisms in 194 cases and 169 healthy controls. Results: Men with the rs1045531 AA genotype were at higher risk for prostate cancer than those with the CC genotype. Individuals with the CCCAGGTACGG haplotype were at significantly increased risk for prostate cancer. When considering clinical factors, rs3736001, which is a nonsynonymous cDNA single nucleotide polymorphism (Glu39Lys), showed an association with prostate specific antigen 10 ng/ml or greater and prostate cancer risk. Conclusions: Men with the rs1045531 AA genotype of PSCA were at higher risk for prostate cancer. 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Volume 185Issue 6June 2011Page: 2112-2118 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Keywordshumanrisksingle nucleotideprostateprostatic neoplasmsPSCA proteinpolymorphismMetricsAuthor Information Jae Young Joung Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea Equal study contribution. More articles by this author Yeon-Su Lee Functional Genomics Branch, National Cancer Center, Goyang, Republic of Korea Equal study contribution. More articles by this author Sohee Park Cancer Biostatistics Branch, National Cancer Center, Goyang, Republic of Korea More articles by this author Hyekyoung Yoon Cancer Biostatistics Branch, National Cancer Center, Goyang, Republic of Korea More articles by this author Sang Jin Lee Genitourinary Cancer Branch, National Cancer Center, Goyang, Republic of Korea More articles by this author Weon Seo Park Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea More articles by this author Ho Kyung Seo Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea More articles by this author Jinsoo Chung Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea More articles by this author Sook-young Kim Functional Genomics Branch, National Cancer Center, Goyang, Republic of Korea More articles by this author Seung-Hyun Hong Functional Genomics Branch, National Cancer Center, Goyang, Republic of Korea More articles by this author Jeong Seon Kim Cancer Epidemiology Branch, National Cancer Center, Goyang, Republic of Korea More articles by this author Kang Hyun Lee Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea More articles by this author Expand All Advertisement PDF downloadLoading ...