Portal de Periódicos da CAPES

Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study

2012; Springer Science+Business Media; Volume: 47; Issue: 12 Linguagem: Inglês

10.1007/s00535-012-0600-5

1435-5922

Takumi Kawaguchi, Atsumasa Komori, Masataka Seike, Shigetoshi Fujiyama, Hiroshi Watanabe, Masatoshi Tanaka, Shotaro Sakisaka, Makoto Nakamuta, Yutaka Sasaki, Makoto Oketani, Toshihiro Hattori, Koichi Katsura, Michio Sata,

Blood groups and transfusion

Eltrombopag is an oral thrombopoietin receptor agonist that stimulates thrombopoiesis and shows higher exposure in East Asian patients than in non-Asian patients. We evaluated the pharmacokinetics, efficacy, and safety of eltrombopag in Japanese patients with thrombocytopenia associated with chronic liver disease (CLD).