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Proton Relaxation Times in Arterial Wall and Atheromatous Lesions in Man

1986; Lippincott Williams & Wilkins; Volume: 21; Issue: 5 Linguagem: Inglês

10.1097/00004424-198605000-00010

1536-0210

Kalevi Soila, P. Nummi, T Ekfors, Manuel Viamonte, Martti Kormano,

Electron Spin Resonance Studies

Soila K, Nummi P, Ekfors T, Viamonte M, Kormano M. Proton relaxation times in arterial wall and atheromatous lesions in man. The proton relaxation times of autopsy samples of arterial intima-media were measured with an NMR spectrometer and results correlated to the microscopically estimated lipid content of the vascular wall. The normal arterial intima-media contained two T1 relaxation components. The short T1 component (T1s) was 90 ± 13 ms and its relative weight was 11%. The long T1 component (T11) was 523 ± 89 ms and relative weight 88%, respectively. The average T2 was 99 ± 18 ms. In diseased vessels, a positive correlation was found between the lipid content of the vessel wall and the relaxation rate of the fast component. Tls of the intima-media was significantly shorter (P<.01) in severe atheromatosis compared with vessels without fat deposition. The results suggest that atheromatous lesions should be best highlighted in spin-echo images by using short TR and TE to suppress the influence of T11 and to avoid (noncontrast contributing) T2 decay of the signal intensity.