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Original Articles: Prostate Cancer: Detailed Preliminary Analysis of Iodine-125 Implantation for Localized Prostate Cancer Using Percutaneous Approach

1995; Lippincott Williams & Wilkins; Volume: 153; Issue: 3S Linguagem: Inglês

10.1016/s0022-5347(01)67626-2

1527-3792

Keith W. Kaye, Douglas J. H. Olson, J. Thomas Payne,

Urologic and reproductive health conditions

No AccessJournal of UrologyClinical Urology: Original Article1 Mar 1995Original Articles: Prostate Cancer: Detailed Preliminary Analysis of Iodine-125 Implantation for Localized Prostate Cancer Using Percutaneous Approach Keith W. Kaye, Douglas J. Olson, and J. Thomas. Payne Keith W. KayeKeith W. Kaye More articles by this author , Douglas J. OlsonDouglas J. Olson More articles by this author , and J. Thomas. PayneJ. Thomas. Payne More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67626-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Recent developments have permitted accurate seed placement and dosimetry for interstitial brachytherapy of selected patients with localized prostate cancer. We present our experience with 76 patients divided into 2 groups. Group 1 included 45 patients with smaller, more well differentiated tumors, usually less than 2 cm. in diameter on digital rectal examination or transrectal ultrasound and a Gleason score of less than 7 who were treated with 125 iodine alone. Group 2 consisted of 31 patients with localized tumors greater than 2 cm. in diameter and/or a Gleason sum equal to or greater than 7 who were treated with low dose external beam radiation followed by 125 iodine boost 4 weeks later. Complete clinical progression-free survival, including prostate specific antigen, digital rectal examination and biopsy, was 51% for group 1 and 63.3% for group 2, with a mean followup of 26.3 months. Prostate specific antigen progression-free survival was 97.7% for group 1 and 94.7% for group 2. These results appear to be superior to external beam radiation only although longer followup is needed to substantiate these favorable early results. The procedures were well tolerated with good potency sparing. They were performed on an outpatient or short stay basis and provided a good alternative to external beam radiation only or hormonal treatment for select patients with localized prostate cancer who may not be candidates for radical prostatectomy. References 1 : Transperineal 125 iodine seed implantation in prostatic cancer guided by transrectal ultrasonography. J. Urol.1983; 130: 283. Link, Google Scholar 2 : Transperineal percutaneous iodine-125 implantation for prostatic carcinoma using transrectal ultrasound and template guidance. Endocurie. Hypertherm. Oncol.1987; 3: 131. Google Scholar 3 : Improved technique for prostate seed implantation: combined ultrasound and fluoroscopic guidance. J. Endourol.1992; 6: 61. Google Scholar 4 : Nonparametric estimation from incomplete observations. J. Amer. Stat. Assoc.1958; 53: 457. Google Scholar 5 : Correlation of radiotherapeutic parameters and treatment related morbidity in carcinoma of the prostate--analysis of RTOG study 75-06. Int. J. 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Google Scholar From the Departments of Urology, Radiation Therapy and Physics, Abbott Northwestern Hospital, Minneapolis, Minnesota© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byHAN B, DEMEL K, WALLNER K, ELLIS W, YOUNG L and RUSSELL K (2018) PATIENT REPORTED COMPLICATIONS AFTER PROSTATE BRACHYTHERAPYJournal of Urology, VOL. 166, NO. 3, (953-957), Online publication date: 1-Sep-2001.BRANDEIS J, LITWIN M, BURNISON C and REITER R (2018) QUALITY OF LIFE OUTCOMES AFTER BRACHYTHERAPY FOR EARLY STAGE PROSTATE CANCERJournal of Urology, VOL. 163, NO. 3, (851-857), Online publication date: 1-Mar-2000.WAGNER T, YOUNG D and BAHNSON R (2018) CHARGE AND LENGTH OF HOSPITAL STAY ANALYSIS OF RADICAL RETROPUBIC PROSTATECTOMY AND TRANSPERINEAL PROSTATE BRACHYTHERAPYJournal of Urology, VOL. 161, NO. 4, (1216-1218), Online publication date: 1-Apr-1999.RAMOS C, CARVALHAL G, SMITH D, MAGER D and CATALONA W (2018) RETROSPECTIVE COMPARISON OF RADICAL RETROPUBIC PROSTATECTOMY AND125 IODINE BRACHYTHERAPY FOR LOCALIZED PROSTATE CANCERJournal of Urology, VOL. 161, NO. 4, (1212-1215), Online publication date: 1-Apr-1999.TERK M, STOCK R and STONE N (2018) IDENTIFICATION OF PATIENTS AT INCREASED RISK FOR PROLONGED URINARY RETENTION FOLLOWING RADIOACTIVE SEED IMPLANTATION OF THE PROSTATEJournal of Urology, VOL. 160, NO. 4, (1379-1382), Online publication date: 1-Oct-1998.ZEITLIN S, SHERMAN J, RABOY A, LEDERMAN G and ALBERT P (2018) HIGH DOSE COMBINATION RADIOTHERAPY FOR THE TREATMENT OF LOCALIZED PROSTATE CANCERJournal of Urology, VOL. 160, NO. 1, (91-96), Online publication date: 1-Jul-1998.Long J, Fallick M, LaRock D and Rand W (2018) PRELIMINARY OUTCOMES FOLLOWING CRYOSURGICAL ABLATION OF THE PROSTATE IN PATIENTS WITH CLINICALLY LOCALIZED PROSTATE CARCINOMAJournal of Urology, VOL. 159, NO. 2, (477-484), Online publication date: 1-Feb-1998.Vicini F, Horwitz E, Gonzalez J and Martinez A (2018) Treatment Options for Localized Prostate Cancer Based on Pretreatment Serum Prostate Specific Antigen LevelsJournal of Urology, VOL. 158, NO. 2, (319-325), Online publication date: 1-Aug-1997. Volume 153Issue 3SMarch 1995Page: 1020-1025 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Keith W. Kaye More articles by this author Douglas J. Olson More articles by this author J. Thomas. Payne More articles by this author Expand All Advertisement PDF downloadLoading ...