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Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis

2004; Elsevier BV; Volume: 77; Issue: 2 Linguagem: Inglês

10.1016/j.pbb.2003.12.003

1873-5177

Sebastián P. Fernández, Cristina Wasowski, Alejandro C. Paladini, Mariel Marder,

Migraine and Headache Studies

We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (−) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleep-inducing properties of HN. The present paper reports the identification in V. officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by simultaneous administration of valerenic acid (VA). These effects should be taken into account when considering the pharmacological actions of valeriana extracts.